16 Result(s)

Article

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), especially the latest Omicron, have exhibited severe antibody evasion. Broadly neutralizing antibodies with high pot...

**aoman Li, Yongbing Pan, Qiangling Yin, Zejun Wang, Sisi Shan… in Cell Discovery (2022)

Article

Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2

Polyamines are important polycations that play critical roles in mammalian cells. ATP13A2 belongs to the orphan P5B adenosine triphosphatases (ATPase) family and has been established as a lysosomal polyamine e...

Xudong Chen, Mingze Zhou, Sensen Zhang, Jian Yin, ** Zhang, Xujun Xuan… in Cell Discovery (2021)

Article

Molecular insights into the human ABCB6 transporter

ABCB6 plays a crucial role in energy-dependent porphyrin transport, drug resistance, toxic metal resistance, porphyrin biosynthesis, protection against stress, and encoding a blood group system Langereis antig...

Guangyuan Song, Sensen Zhang, Mengqi Tian, Laixing Zhang, Runyu Guo… in Cell Discovery (2021)

Article

Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis

Pannexin1 (PANX1) is a large-pore ATP efflux channel with a broad distribution, which allows the exchange of molecules and ions smaller than 1 kDa between the cytoplasm and extracellular space. In this study, ...

Sensen Zhang, Baolei Yuan, Jordy Homing Lam, Jun Zhou, Xuan Zhou… in Cell Discovery (2021)

Article

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

NKCC and KCC transporters mediate coupled transport of Na⁺+K⁺+Cl⁻ and K⁺+Cl⁻ across the plasma membrane, thus regulating cell Cl⁻ concentration and cell volume and playing critical roles in transepithelial salt a...

Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel… in Communications Biology (2021)

Article

Atomic structure of human TOM core complex

The translocase of the outer mitochondrial membrane (TOM) complex is the main entry gate for mitochondrial precursor proteins synthesized on cytosolic ribosomes. Here we report the single-particle cryo-electro...

Wenhe Wang, Xudong Chen, Laixing Zhang, **gbo Yi, Qingxi Ma, Jian Yin… in Cell Discovery (2020)

Article

Structure of the intact 14-subunit human cytochrome c oxidase

Respiration is one of the most basic features of living organisms, and the electron transport chain complexes are probably the most complicated protein system in mitochondria. Complex-IV is the terminal enzyme...

Shuai Zong, Meng Wu, **ke Gu, Tianya Liu, Runyu Guo, Maojun Yang in Cell Research (2018)

Article

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Acid-sensing ion channels (ASICs) are neuronal voltage-independent Na⁺ channels that are activated by extracellular acidification. ASICs play essential roles in a wide range of physiological processes, including ...

Demeng Sun, You Yu, **aobin Xue, Man Pan, Ming Wen, Siyu Li, Qian Qu… in Cell Discovery (2018)

Article

Structural insights into the TRIM family of ubiquitin E3 ligases

Yang Li, Han Wu, Wei Wu, Wei Zhuo, Weixiao Liu, Yixiao Zhang… in Cell Research (2014)

Article

Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters

The energy-coupling factor (ECF) transporters are multi-subunit protein complexes that mediate uptake of transition-metal ions and vitamins in about 50% of the prokaryotes, including bacteria and archaea. Biol...

You Yu, Mingze Zhou, Franziska Kirsch, Congqiao Xu, Li Zhang, Yu Wang… in Cell Research (2014)