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  1. No Access

    Article

    Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

    AMPK (AMP-activated protein kinase) senses cellular energy status to maintain a balance between ATP production and consumption and has important roles in regulating cell growth and proliferation. Here, crystal...

    Lei Chen, Zhi-Hao Jiao, Li-Sha Zheng, Yuan-Yuan Zhang, Shu-Tao **e, Zhi-**n Wang in Nature (2009)

  2. No Access

    Article

    Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese family

    Pseudohypoparathyroidism (PHP) is a heterogeneous group of diseases characterized by hormone resistance to receptors that stimulate adenylate cyclase. PHP-Ia patients show specific Gs-alpha protein deficiency,...

    Li-Hao Sun, Bin Cui, Hong-Yan Zhao, Bei Tao, Wei-Qing Wang, **ao-Ying Li in Endocrine (2009)

  3. Article

    Open Access

    Whole-genome analysis informs breast cancer response to aromatase inhibition

    To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant ar...

    Matthew J. Ellis, Li Ding, Dong Shen, **gqin Luo, Vera J. Suman, John W. Wallis in Nature (2012)

  4. Article

    Open Access

    Evaluation of Ca3Co2O6 as cathode material for high-performance solid-oxide fuel cell

    A cobalt-based thermoelectric compound Ca3Co2O6 (CCO) has been developed as new cathode material with superior performance for intermediate-temperature (IT) solid-oxide fuel cell (SOFC). Systematic evaluation has...

    Tao Wei, Yun-Hui Huang, Rui Zeng, Li-**a Yuan, **an-Luo Hu in Scientific Reports (2013)

  5. No Access

    Article

    The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women

    To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and ...

    Yan-Hua Deng, Lin Zhao, Min-Jia Zhang, Chun-Ming Pan, Shuang-**a Zhao in Endocrine (2013)

  6. Article

    Open Access

    Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing

    Quantum dots (QDs) have attracted increasing interest in bioimaging and sensing. Here, we report a biosensor of complex I using ubiquinone-terminated disulphides with different alkyl spacers (QnNS, n = 2, 5 and...

    Wei Ma, Li-**a Qin, Feng-Tao Liu, Zhen Gu, Jian Wang, Zhi Gang Pan in Scientific Reports (2013)

  7. Article

    Correction: Corrigendum: Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing

    Quantum dots (QDs) have attracted increasing interest in bioimaging and sensing. Here, we report a biosensor of complex I using ubiquinone-terminated disulphides with different alkyl spacers (QnNS, n = 2, 5 and...

    Wei Ma, Li-**a Qin, Feng-Tao Liu, Zhen Gu, Jian Wang, Zhi Gang Pan in Scientific Reports (2013)

  8. Article

    Open Access

    Top–down fabrication of sub-nanometre semiconducting nanoribbons derived from molybdenum disulfide sheets

    Developments in semiconductor technology are propelling the dimensions of devices down to 10 nm, but facing great challenges in manufacture at the sub-10 nm scale. Nanotechnology can fabricate nanoribbons from...

    **aofei Liu, Tao Xu, **ng Wu, Zhuhua Zhang, ** Yu, Hao Qiu in Nature Communications (2013)

  9. Article

    Open Access

    Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu

    Complex environmental conditions can significantly affect bacterial genome size by unknown mechanisms. The So0157-2 strain of Sorangium cellulosum is an alkaline-adaptive epothilone producer that grows across a w...

    Kui Han, Zhi-feng Li, Ran Peng, Li-** Zhu, Tao Zhou, Lu-guang Wang in Scientific Reports (2013)

  10. Article

    Open Access

    Contribution of NKX2-3 Polymorphisms to Inflammatory Bowel Diseases: A Meta-Analysis of 35358 subjects

    Polymorphisms in NKX2-3 gene have been inconsistently associated with Crohn's disease (CD) and ulcerative colitis (UC). To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD o...

    **aoCheng Lu, Linjun Tang, Kai Li, **Yu Zheng, Penglai Zhao, Yi Tao in Scientific Reports (2014)

  11. No Access

    Article

    Association of hematological parameters with metabolic syndrome in Bei**g adult population: a longitudinal study

    The purposes of the study were to estimate the incidence of metabolic syndrome (MetS) and to systematically evaluate the relationship between hematological parameters and MetS in a 5-year follow-up of Bei**g ...

    Li-**n Tao, **a Li, Hui-** Zhu, Da Huo, Tao Zhou, Lei Pan, Yan-**a Luo in Endocrine (2014)

  12. No Access

    Article

    Risk profiles for metabolic syndrome and its transition patterns for the elderly in Bei**g, 1992–2009

    There have been few reports on the development of metabolic disorders, especially when they are considered as a cluster. The purpose of this study was to describe risk profiles for metabolic syndrome (MetS) in...

    Li-**n Tao, Wei Wang, Hui-** Zhu, Da Huo, Tao Zhou, Lei Pan, Qi Gao in Endocrine (2014)

  13. No Access

    Article

    Structures of bacterial homologues of SWEET transporters in two distinct conformations

    The X-ray crystal structures of two bacterial homologues of the SWEET sugar transporters are solved in two conformational states, and comparison of these states suggests that transport occurs via a ‘rocker-swi...

    Yan Xu, Yuyong Tao, Lily S. Cheung, Chao Fan, Li-Qing Chen, Sophia Xu, Kay Perry in Nature (2014)

  14. No Access

    Article

    IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats

    Interleukin 15 (IL-15) has recently been proposed as a circulating myokine involved in glucose uptake and utilization in skeletal muscle. However, the role and mechanism of IL-15 in exercise improving insulin ...

    Hong-Tao Yang, Li-Jie Luo, Wen-Jia Chen, Lei Zhao, Chao-Shu Tang, Yong-Fen Qi in Endocrine (2015)

  15. Article

    Open Access

    Magnetic properties in α-MnO2 doped with alkaline elements

    α-MnO2 nanotubes were fabricated using a hydrothermal technique. Li, Na and K ions were introduced into MnO2 nanotubes to tailor their magnetic properties. It was found that with a do** concentration lower than...

    Li-Ting Tseng, Yunhao Lu, Hai Ming Fan, Yiren Wang, ** Luo, Tao Liu in Scientific Reports (2015)

  16. Article

    Open Access

    Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

    Metabolic alteration is a hallmark of cancer. Dysregulation of methionine metabolism is implicated in human liver cancer. Methionine adenosyltransferase IIα (MAT IIα) is a key enzyme in the methionine cycle, c...

    Hong-Bin Yang, Ying-Ying Xu, **ang-Ning Zhao, Shao-Wu Zou in Nature Communications (2015)

  17. Article

    Open Access

    Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice

    A novel neuropeptide spexin was found to be broadly expressed in various endocrine and nervous tissues while little is known about its functions. This study investigated the role of spexin in bowel movement an...

    Cheng-yuan Lin, Man Zhang, Tao Huang, Li-ling Yang, Hai-bo Fu in Scientific Reports (2015)

  18. Article

    Open Access

    The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells

    Pancreatic cancer is one of the more common cancers with a poor prognosis. Some varieties of cancer are related to virus infection. As a virus-induced protein, APOBEC3G (A3G) presents extensive anti-virus abil...

    Jia Wu, Tian-Hui Pan, Song Xu, Li-Tao Jia, Lin-Lin Zhu, Jian-Shan Mao in Scientific Reports (2015)

  19. Article

    Open Access

    A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

    Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs) and antigenic drift in a particular HA. Here we pr...

    Ying Wu, MyungSam Cho, David Shore, Manki Song, JungAh Choi in Nature Communications (2015)

  20. Article

    Open Access

    Diversity and distribution of lichen-associated fungi in the Ny-Ålesund Region (Svalbard, High Arctic) as revealed by 454 pyrosequencing

    This study assessed the diversity and distribution of fungal communities associated with seven lichen species in the Ny-Ålesund Region (Svalbard, High Arctic) using Roche 454 pyrosequencing with fungal-specifi...

    Tao Zhang, **n-Li Wei, Yu-Qin Zhang, Hong-Yu Liu, Li-Yan Yu in Scientific Reports (2015)

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