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1,156 Result(s)
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Article
Genomic mismatch scanning: a new approach to genetic linkage map**
Genomic mismatch scanning (GMS) is a new method of genetic linkage analysis that does not require conventional polymorphic markers or gel electrophoresis. GMS is ideally suited to affected–relative–pair mappin...
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Mosaic and polymorphic imprinting of the WT1 gene in humans
We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expres...
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Establishment of functional imprinting of the H19 gene in human develo** placentae
We have found that the imprinted H19 gene can be expressed either biallelically or monoallelically in the develo** human placentae. H19 biallelic expression is confined to the placenta until 10 weeks of gestati...
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Differential adhesion of metastatic RAW117 large-cell lymphoma cells under static or hydrodynamic conditions: role of integrin alpha v beta3
RGD-containing substrates were used to study static and hydrodynamic adhesion of murine RAW117 large-cell lymphoma sublines with differential liver-metastatic potentials. Highly liver-metastatic RAW117-H10 cel...
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Article
Chromosomal deletion complexes in mice by radiation of embryonic stem cells
Chromosomal deletions (‘deficiencies’) are powerful tools in the genetic analysis of complex genomes. They have been exploited extensively in Drosophila melanogaster, an organism in which deficiencies can be effi...
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Keratin 19 mRNA is detectable by RT-PCR in lymph nodes of patients without breast cancer
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Article
Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential
The ribonucleotide reductase (RR) gene has been associated with malignant transformation and metastatic potential. In this report, the significance of the expression of RR mRNA and enzymatic activity to the in...
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Practical Considerations in Converting from Plasma-Derived to Recombinant Hepatitis B Vaccines
Plasma-derived and recombinant vaccines have been developed to prevent hepatitis B virus infections. Both types of vaccine perform very well with respect to safety, immunogenicity and protective efficacy. The ...
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Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment
Hearing impairment is the most commonly occurring condition that affects the ability of humans to communicate 1 . More than 50%...
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Open AccessAnalysis of potential markers for detection of submicroscopic lymph node metastases in breast cancer
We have developed sensitive assays for cytokeratin (K) 8, 16, 19, stromelysin 3 (ST3), MUC1 and maspin mRNAs using reverse transcription polymerase chain reaction (RT-PCR) and used these to assess lymph node s...
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Article
Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1
Angiogenesis inhibitors produced by a primary tumor can create a systemic anti-angiogenic environment and maintain metastatic tumor cells in a state of dormancy1,2. We show here that the gallbladder microenvironm...
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Article
Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
Transplantation approaches using cellular bridges1,2, fetal central nervous system cells3,4,5, fibroblasts expressing neurotrophin-3 (ref. 6), hybridoma cells expressing inhibitory protein-blocking antibodies7, o...
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The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease
Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart...
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Article
The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence
Objective: We have reviewed the potential cancer-preventive and other relevant properties of Panax ginseng C. A. Meyer, which has been traditionally used as a natural tonic in Oriental countries.
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Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat1 results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retina...
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Article
A biochemical function for attractin in agouti-induced pigmentation and obesity
Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (Ay) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the ...
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Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy
The chromophore of the visual pigments, 11-cis retinal, is derived from vitamin A (all-trans retinol) through a series of reactions that take place in retinal pigment epithelium (RPE); (ref. 1). The first of thes...
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Article
Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both g...
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Article
Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis
Mutations in Rpe65 disrupt synthesis of the opsin chromophore ligand 11-cis-retinal and cause Leber congenital amaurosis (LCA), a severe, early-onset retinal dystrophy. To test whether light-independent signaling...
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Expression of androgen receptor and prostate-specific antigen in male breast carcinoma
The androgen-regulated proteins prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are present in high concentrations in normal prostate and prostatic cancer and are considered to be...