8 Result(s)
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Article
Kay Washington
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Article
Open AccessApc-related models of intestinal neoplasia: a brief review for pathologists
Rodent models of intestinal cancer are widely used as preclinical models for human colorectal carcinoma and have proven useful in many experimental contexts, including elucidation of basic pathways of carcinog...
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Open AccessActivation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesop...
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A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis o...
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Open AccessCurrent applications of molecular pathology in colorectal carcinoma
Molecular pathology is playing an increasingly important role in the treatment and overall management of patients with colorectal carcinoma. Three distinct genetic pathways have been identified that play a rol...
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Open AccessIntegrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas
The incidence of esophageal adenocarcinoma (EAC) is rapidly rising in the United States and Western countries. In this study, we carried out an integrative molecular analysis to identify interactions between g...
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Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett’s esophagus
Endoscopic therapy has emerged as an alternative to surgical esophagectomy for the management of Barrett’s esophagus (BE)-associated neoplasia. Accurate pretreatment staging is essential to ensure an appropria...
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Open AccessTargeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identifi...
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Functional studies on the anti-pathoangiogenic properties of CM101
Group B streptococcus (GBS) isolated from human neonates diagnosed with sepsis and respiratory distress produces a polysaccharide exotoxin (CM101) which has been previously described as GBS toxin. CM101 infuse...
