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Article
Pyrazine Derivatives—Versatile Scaffold
Pyrazines are important class of pharmacophores because of their versatility in pharmacological activity. Pyrazines are among the most widely known heterocyclic compounds those can be isolated from natural sou...
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Article
Open AccessABVD and BEACOPP regimens’ effects on fertility in young males with Hodgkin lymphoma
Considering the increased cancer patient survivorship, the focus is now on addressing the impacts of treatment on quality of life. In young people, altered reproductive function is a major issue and its effect...
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Article
Open AccessSystematic review of the use of translated patient-reported outcome measures in cancer trials
Patient-reported outcomes (PROs) are used in clinical trials to assess the effectiveness and tolerability of interventions. Inclusion of participants from different ethnic backgrounds is essential for generali...
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Article
Enhanced Dai–Liao conjugate gradient methods for systems of monotone nonlinear equations
In this paper, we propose two conjugate gradient methods for solving large-scale monotone nonlinear equations. The methods are developed by combining the hyperplane projection method by Solodov and Svaiter (Re...
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Article
Open AccessA Dai–Liao conjugate gradient method via modified secant equation for system of nonlinear equations
In this paper, we propose a Dai–Liao (DL) conjugate gradient method for solving large-scale system of nonlinear equations. The method incorporates an extended secant equation developed from modified secant equ...
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Article
Open AccessSubstantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan: evidence from two longitudinal cohort studies 15 years apart
Oshikhandass is a rural village in northern Pakistan where a 1989–1991 verbal autopsy study showed that diarrhea and pneumonia were the top causes of under-5 mortality. Intensive surveillance, active community...
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Article
Open AccessExperimental Validation of an ITAP Numerical Model and the Effect of Implant Stem Stiffness on Bone Strain Energy
The Intraosseous Transcutaneous Amputation Prosthesis (ITAP) offers transfemoral amputees an ambulatory method potentially reducing soft tissue complications seen with socket and stump devices. This study vali...
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Article
Pros and cons of using wavelets in conjunction with genetic programming and generalised linear models in statistical downscaling of precipitation
Among the regression techniques used in building statistical downscaling models, genetic programming (GP) which mimics Darwin’s theory of biological evolution possesses several pros such as it evolves explicit...
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Article
Open AccessUse of geophysical logs in hydrogeological studies and borehole designs: case study of Apapa coastal area, Lagos, Nigeria
The hydrogeological study of Apapa, a coastal part of Lagos, Nigeria, has been investigated using combined geophysical borehole logs, consisting of natural gamma and electrical resistivity components and ditch...
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Article
Open AccessAn analysis of two classes of phase field models for void growth and coarsening in irradiated crystalline solids
A formal asymptotic analysis of two classes of phase field models for void growth and coarsening in irradiated solids has been performed to assess their sharp-interface kinetics. It was found that the sharp in...
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Article
Are wound ring protectors effective in reducing surgical site infection post appendectomy? A systematic review and meta-analysis
Surgical site infection (SSI) is one of the main causes of postoperative morbidity and mortality. Appendectomy for acute appendicitis is one of the most commonly performed surgical interventions worldwide. The...
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Article
Phase field modeling for grain growth in porous solids
Concurrent evolution of grain size and porosity in solids is a technically important problem involving curvature-driven motion of grain boundaries and the pore motion by surface diffusion. A phase field approa...
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Article
Medfest: the Effect of a National Medical Film Festival on Attendees’ Attitudes to Psychiatry and Psychiatrists and Medical Students’ Attitudes to a Career in Psychiatry
The authors proposed that a national film festival organized by psychiatrists could change attendees’ views toward psychiatry and psychiatrists positively and increase the numbers of medical students consideri...
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Article
Ethnic differences in the number of miscarriages, number of children, perceived family support and the impact of the disease on daily living in patients with systemic lupus erythematosus
Our aim was to test for ethnic differences in the number of children, number of miscarriages, family support and the impact of the disease on daily living among patients with systemic lupus erythematosus (SLE)...
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Article
Stress as a trigger of disease flares in SLE
Patients with systemic lupus erythematosus were asked to report their perceptions as to whether stress can trigger disease flares. A total of 54 patients treated at two District General Hospitals in Essex were...
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Article
Search for a signal on QCD critical point in central nucleusnucleus collisions
We discuss that the QCD critical point could appear in central collisions in percolation cluster. We suggest to use the effects of nuclear transparency and that of the light nuclear production to identify the ...
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Article
Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton
Ubiquitous protein kinase CK2 is a key regulator of cell migration, proliferation and tumor growth. CK2 is abundant in retinal astrocytes, and its inhibition suppresses retinal neovascularization in a mouse re...
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Article
Effect of Rapid Thermal Oxidation on Blue and Red Luminescence Bands of Porous Silicon
Photoluminescence (PL) of porous silicon after rapid thermal oxidation was studied using excitation energies of 5.0 and 6.4 eV. The emission spectra in both cases are dominated by a broad blue band centered at...
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Article
Protein Kinase CK2 in Health and Disease
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been associated with increased cell growth and proliferation both in normal and cancer cells. The ability of CK2 to also act as ...
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Article
Mineral profile of Ghanaian dried tobacco leaves and local snuff: A comparative study
The concentration of thirty-four elements each in Ghanaian dried tobacco leaves and snuff (powdered tobacco) have been determined using instrumental neutron activation analysis (INAA). The concentration of Hg,...
