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    Article

    Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro

    The repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of ...

    K. S. Zhuvaka, G. P. Volynets, T. P. Ruban, Z. M. Nidoeva… in Cytology and Genetics (2023)

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    Article

    Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton

    Ubiquitous protein kinase CK2 is a key regulator of cell migration, proliferation and tumor growth. CK2 is abundant in retinal astrocytes, and its inhibition suppresses retinal neovascularization in a mouse re...

    A. A. Kramerov, A. G. Golub, V. G. Bdzhola… in Molecular and Cellular Biochemistry (2011)