8 Result(s)
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Article
Jeremy Wang
English
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Article
Masking T cell engagers mitigates on-target off-tumor activity
Clinical utility of T cell engagers (TCEs) in cancer immunotherapy for solid tumors is hampered by on-target off-tumor activity and dose-limiting adverse events. A study now proposes a solution to tackle these...
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Urine DNA biomarkers for hepatocellular carcinoma screening
Hepatocellular carcinoma (HCC) occurs in a well-defined high-risk patient population, but better screening tests are needed to improve sensitivity and efficacy. Therefore, we investigated the use of urine circ...
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Carbon fiber–aluminum sandwich for micro-aerial vehicles and miniature robots
We present carbon-fiber and aluminum sandwich plates with millimeter thicknesses that exhibit high stiffness- and strength-to-weight ratios. These composites consist of carbon-fiber-reinforced polymer faces an...
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Open AccessDevelopment and Evaluation of Novel Statistical Methods in Urine Biomarker-Based Hepatocellular Carcinoma Screening
Hepatocellular carcinoma is one of the fastest growing cancers in the US and has a low survival rate, partly due to difficulties in early detection. Because of HCC’s high heterogeneity, it has been suggested t...
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Alpha-fetoprotein-producing esophageal adenocarcinoma: a mimicker of hepatocellular carcinoma
Alpha-fetoprotein (AFP)-producing esophageal adenocarcinoma (EAC) is a rare occurrence. Elevation of serum AFP is commonly associated with hepatocellular carcinoma and yolk sac tumors, but rarely with esophage...
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Erratum to: Status and access to the Collaborative Cross population
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RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis
Neil Hunter and colleagues show that RNF212 is essential for crossing-over during mammalian meiosis and functions to couple chromosome synapsis to the formation of crossover-specific recombination complexes. T...
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Open AccessStatus and access to the Collaborative Cross population
The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC population was reported based ...
