![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Erratum: Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling
Correction to: Oncogene (2017) 36, 4235–4242; doi:10.1038/onc.2016.394; published online 21 November 2016 Since the online publication of this article the authors noticed an incorrect version of Figure 4c was ...
-
Article
Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling
Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current treatment...
-
Article
Open AccessThe ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids
High thymidylate synthase (TS) level in cancer tissue is considered to result in resistance to pemetrexed therapy for advanced stages of nonsquamous non-small cell lung cancers. To further investigate the mech...
-
Article
Open AccessInhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties
Advanced prostate adenocarcinomas enriched in stem-cell features, as well as variant androgen receptor (AR)-negative neuroendocrine (NE)/small-cell prostate cancers are difficult to treat, and account for up t...
-
Article
Open AccessPhosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth
Metastatic competence is contingent upon the aberrant activation of a latent embryonic program, known as the epithelial–mesenchymal transition (EMT), which bestows stem cell properties as well as migratory and...
-
Article
Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents
Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced. These tumors acquire ectopic Arg for survival, and depleting this source by...
-
Article
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness
The four R-spondins (RSPO1–4) and their three related receptors LGR4, 5 and 6 (LGR4–6) have emerged as a major ligand-receptor system with critical roles in development and stem cell survival through modulatio...
-
Article
GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer
The epithelial–mesenchymal transition (EMT) bestows cancer cells with increased stem cell properties and metastatic potential. To date, multiple extracellular stimuli and transcription factors have been shown ...
-
Article
Grp78 as a therapeutic target for refractory head–neck cancer with CD24−CD44+ stemness phenotype
Cancer stem cells are refractory to conventional therapy, which result to cancer metastasis and chemo-radioresistance. Grp78 is known to have important roles in cytoprotection and tumorigenesis in several canc...
-
Article
Aryl hydrocarbon receptor in association with RelA modulates IL-6 expression in non-smoking lung cancer
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is activated by cigarette smoke. Previously, we demonstrated that AhR is overexpressed in lung adenocarcinomas (ADs). In this stu...
-
Article
Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-κB activation
Apurinic endonuclease 1 (Ape1) is not only involved in base excision repair, but also activates some transcriptional factors through its redox activity. However, which subcellular localization of Ape1 is invol...
-
Article
Anchorage-independent cell growth signature identifies tumors with metastatic potential
The oncogenic phenotype is complex, resulting from the accumulation of multiple somatic mutations that lead to the deregulation of growth regulatory and cell fate controlling activities and pathways. The abili...
-
Article
A combinatorial mechanism for determining the specificity of E2F activation and repression
Various studies have detailed the role of E2F proteins in both transcription activation and repression. Further study has shown that distinct promoter elements, but comprising the same E2F-recognition motif, c...
-
Article
Compensation and specificity of function within the E2F family
Functions encoded by single genes in lower organisms are often represented by multiple related genes in the mammalian genome. An example is the retinoblastoma and E2F families of proteins that regulate transcr...
-
Article
DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis
To identify genes that could potentially serve as molecular therapeutic markers for human head and neck cancer (HNC), we employed differential display analysis to compare the gene expression profiles between H...
-
Article
Open AccesshTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells
Telomerase activity is suppressed in normal somatic tissues but is activated in most cancer cells. We have previously found that all six telomerase subunit proteins, including hTERT and hsp90 are needed for fu...
-
Article
Open AccessPrognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area
Although several studies have found overexpression of epidermal growth factor receptor (EGFR) proteins EGFR and Her-2 in head and neck cancers, the clinical relevance of the finding varies. We examined the exp...
-
Article
No evidence of porcine endogenous retrovirus infection in bioartificial skin composed of porcine dermal matrix
Xenotransplantation of pig organs and tissues to humans involves a risk of infection by porcine endogenous retrovirus (PERV). This investigation examined potential transmission of PERV by using an in vitro cu...
-
Article
Integrating genotype and phenotype information: an overview of the PharmGKB project
-
Article
Electroplating of Ni-Cr on steel with pulse plating
It has been difficult to electrolytically obtain crack- free chromium plating because of the high stresses caused by several factors. Accordingly, electroplating of nickel- chromium also encounters a similar p...