16 Result(s)

Article

Results, meta-analysis and a first evaluation of U_NOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO₂⁻), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endo...

Dimitrios Tsikas, Erik Hanff, Alexander Bollenbach, Ruan Kruger, Vu Vi Pham… in Amino Acids (2018)

Article

Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease

Elevated circulating concentrations of total l-homocysteine (thCys) and free asymmetric dimethylarginine (ADMA) are long-established cardiovascular risk factors. Low circulating l-homoarginine (hArg) concentratio...

Arslan Arinc Kayacelebi, Janina Willers, Vu Vi Pham, Andreas Hahn… in Amino Acids (2015)

Article

Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis, whereas l-arginine (Arg) and l-homoarginine (hArg) serve as substrates for NO synthesis. ADMA and other methylated arg...

Arslan Arinc Kayacelebi, Jennifer Langen, Katharina Weigt-Usinger… in Amino Acids (2015)

Article

Effects of chronic oral l-arginine administration on the l-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: l-Arginine prevents renal loss of nitrite, the major NO reservoir

Despite saturation of nitric oxide (NO) synthase (NOS) by its substrate l-arginine (Arg), oral and intravenous supplementation of Arg may enhance NO synthesis, a phenomenon known as “The l-arginine paradox”. Yet,...

Jessica Y. Schneider, Sabine Rothmann, Frank Schröder, Jennifer Langen… in Amino Acids (2015)

Article

Aortic thrombus and pulmonary embolism in a patient with hyperhomocysteinemia

Background A 32-year-old man presented at hospital with persistent pain, hypothermia and paraesthesia in his right leg, caused by embolic occlusion of all three large arteries as a result of massive thrombi in th...

Andreas Goette, Matthias Hammwöhner… in Nature Clinical Practice Cardiovascular Me… (2006)

Article

Pregraduate teaching clinical pharmacology in Germany

Dirk O. Stichtenoth, Jürgen C. Frölich in European Journal of Clinical Pharmacology (2004)

Article

Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers

Carvedilol is a nonselective β- and α₁-receptor antagonist with additional antioxidant properties in vitro. In this study, we assessed the antioxidative potential of carvedilol in cell culture and in antihyperten...

Stefanie A. Fahlbusch, Dimitrios Tsikas… in European Journal of Clinical Pharmacology (2004)

Article

The Second Generation of COX-2 Inhibitors

The discovery of two cyclooxygenase (COX)-isoenzymes, a constitutive OX-1, serving homeostatic prostanoid synthesis, and an inducible COX-2, responsible for proinflammatory prostanoid production, led to the de...

Dr Dirk O. Stichtenoth, Jürgen C. Frölich in Drugs (2003)

Article

Blood donors on medication

Objectives: Drugs and their metabolites in transfused blood components may cause effects in the recipient. If the treated disorder is not to be regarded as an exclusion criterion from blood donation, donors on m...

Dirk O. Stichtenoth, Helmuth R. Deicher… in European Journal of Clinical Pharmacology (2001)

Article

Neue nichtsteroidale Antirheumatika: Selektive Hemmstoffe der induzierbaren Cyclooxygenase

Nichtsteroidale Antirheumatika (NSAR) üben ihre antiinflammatorischen, analgetischen und antipyretischen Wirkungen durch Hemmung der Prostanoidsynthese aus. Die typischen Nebenwirkungen der NSAR und deren Inte...

Dirk O. Stichtenoth, Henning Zeidler, Jürgen C. Frölich in Medizinische Klinik (1998)

Article

Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro

We compared the effects of L-arginine (L-ARG), the precursor of endogenous NO, on platelet aggregation and thromboxane A₂ formation in vivo and in vitro. Human platelet-rich plasma (PRP) was anticoagulated with c...

S. M. Bode-Böger, Rainer H. Böger… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1998)

Article

Analysis of leukotriene B₄ as free acid and its δ-lactone by high-performance liquid chromatography: a study on the stability and formation of leukotriene B₄ δ-lactone

Reversed-phase high-performance liquid chromatography (RP-HPLC) with UV detection (270 nm) was applied to study the stability of LTB₄ δ-lactone in aqueous solutions and its chemical formation from LTB₄. LTB₄ δ-la...

Dimitrios Tsikas, Joachim Fauler… in Fresenius' Journal of Analytical Chemistry (1993)

Article

Determination of nitrite as pentafluorobenzyl derivative by RP-HPLC and UV detection with and without ion-pair extraction

A reversed-phase high-performance liquid chromatographic (RP-HPLC) method with UV detection (270 nm) for the determination of nitrite as its pentafluorobenzyl derivative with and without ion-pair extraction is...

Dimitrios Tsikas, Jürgen C. Frölich in Fresenius' Journal of Analytical Chemistry (1992)

Article

Analysis of nitrite and nitrate as 1-nitro-2,4,6-trimethoxybenzene derivatives by reversed-phase HPLC with UV-detection

A reversed-phase HPLC method for the determination of nitrite and nitrate in aqueous solutions, biological buffers and human urine is described. The method is based on the conversion of nitrite and nitrate int...

Dimitrios Tsikas, Frank-Mathias Gutzki… in Fresenius' Journal of Analytical Chemistry (1992)

Article

Thimerosal induces endothelium-dependent vascular smooth muscle relaxations by interacting with thiol groups

1. The sulfhydryl reagent thimerosal, as well as acetylcholine and Ca²⁺-ionophore A23187, produced concentration...

Ulrich Förstermann, Karin Burgwitz… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1986)