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  1. Article

    Open Access

    Prognostic value of tumour volume in patients with a poor Karnofsky performance status scale – a bicentric retrospective study

    Median overall survival (OS) after diagnosis of glioblastoma (GBM) remains 15 months amongst patients receiving aggressive surgical resection, chemotherapy and irradiation. Treatment of patients with a poor pr...

    Melanie Barz, Julia Gerhardt, Stefanie Bette, A. Kaywan Aftahy in BMC Neurology (2021)

  2. Article

    Open Access

    Proposed definition of competencies for surgical neuro-oncology training

    The aim of this work is to define competencies and entrustable professional activities (EPAs) to be imparted within the framework of surgical neuro-oncological residency and fellowship training as well as the ...

    Marcel A. Kamp, Bastian Malzkorn, Christiane von Sass in Journal of Neuro-Oncology (2021)

  3. Article

    Open Access

    Integrative assessment of brain and bone invasion in meningioma patients

    Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the re...

    Kerstin Zwirner, Frank Paulsen, Jens Schittenhelm, Irina Gepfner-Tuma in Radiation Oncology (2019)

  4. Article

    Open Access

    COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

    Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2. This has also been investigated in vestibular schwannomas with pro...

    Felix Behling, Vanessa Ries, Marco Skardelly in Acta Neuropathologica Communications (2019)

  5. No Access

    Article

    Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study

    To assess the predictive value of magnetic resonance imaging (MRI) gadolinium enhancement as a prognostic factor in the 2016 World Health Organization Classification of Tumors of the Central Nervous System int...

    Johann-Martin Hempel, Cornelia Brendle, Benjamin Bender in Journal of Neuro-Oncology (2018)

  6. Article

    Open Access

    Sunitinib added to FOLFIRI versus FOLFIRI in patients with chemorefractory advanced adenocarcinoma of the stomach or lower esophagus: a randomized, placebo-controlled phase II AIO trial with serum biomarker program

    As a multi-targeted anti-angiogenic receptor tyrosine kinase (RTK) inhibitor sunitinib (SUN) has been established for renal cancer and gastrointestinal stromal tumors. In advanced refractory esophagogastric ca...

    Markus Moehler, Irina Gepfner-Tuma, Annett Maderer, Peter C. Thuss-Patience in BMC Cancer (2016)