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Article
The sinking platform test: a novel paradigm to measure persistence in animal models
Persistence is the propensity to maintain goal-directed actions despite adversities. While this temperamental trait is crucial to mitigate depression risk, its neurobiological foundations remain elusive. Devel...
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Article
Open AccessIdentification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer’s disease and related tauopathies
Evidence indicates that tau hyper-phosphorylation and subsequent neurofibrillary tangle formation contribute to the extensive neuronal death in Alzheimer’s disease (AD) and related tauopathies. Recent work has...
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Article
Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations
The lack of effective treatments for Alzheimer’s disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated ho...