16 Result(s)

Article

Correction: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li, Zhongyu **e, Peng Wang, **teng Li, Wenjie Liu, Su’an Tang… in Cell Death & Disease (2024)

Article

EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3

Chemoresistance is the main obstacle in the clinical treatment of osteosarcoma (OS). In this study, we investigated the role of EF-hand domain-containing protein 1 (EFHD1) in OS chemotherapy resistance. We fou...

**n Shen, Mengjun Ma, Rujia Mi, Jiahao Zhuang… in Cellular and Molecular Life Sciences (2024)

Article

Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis

Increasing evidence indicates that circular RNAs (circRNAs) accumulate in aging tissues and nonproliferating cells due to their high stability. However, whether upregulation of circRNA expression mediates stem...

Fenglei Chen, Shan Wang, Chenying Zeng, Su’an Tang… in Cellular and Molecular Life Sciences (2023)

Article

Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis

An imbalance of human mesenchymal stem cells (hMSCs) adipogenic and osteogenic differentiation is crucial in the pathogenesis of osteoporosis, and elucidation of the underlying mechanism is urgently needed. AP...

Yunhui Zhang, Wenjie Liu, Weiquan Yuan… in Cellular and Molecular Life Sciences (2022)

Article

Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4⁺ T cells

The immune system and the skeletal system have complex interactions in the bone marrow and even in the joints, which has promoted the development of the concept of osteoimmunology. Some evidence has indicated ...

Feng Ye, **teng Li, Peitao Xu, Zhongyu **e, Guan Zheng… in Stem Cell Research & Therapy (2022)

Article

The N⁶-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6

N⁶-methyladenosine (m⁶A) modification is widespread in messenger RNAs and increasing evidence suggests the crucial roles of m⁶A in cell differentiation and tissue development. However, whether m⁶A modulates the o...

Zhaofeng Li, Peng Wang, **teng Li, Zhongyu **e, Shuizhong Cen… in Cell Death & Disease (2021)

Article

Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease possessing a morbid serum microenvironment with enhanced oxidative stress. Long-term exposure to an oxidative environment usually results in cellul...

Guiwen Ye, Zhongyu **e, Huiqiong Zeng, Peng Wang, **teng Li… in Cell Death & Disease (2020)

Article

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

TNF receptor-associated factor 4 (TRAF4), a member of the TRAF family, plays an important role in the embryogenesis and development of the bone system. Mesenchymal stem cells (MSCs), which are the primary orig...

**teng Li, Peng Wang, Zhongyu **e, Shan Wang… in Cell Death & Differentiation (2019)

Article

Autophagy enhances mesenchymal stem cell-mediated CD4⁺ T cell migration and differentiation through CXCL8 and TGF-β1

Mesenchymal stem cells (MSCs) have been recognized as a promising tool for the treatment of various inflammatory disorders and autoimmune diseases. Stress conditions affect immune-mediated treatment and activa...

Shuizhong Cen, Peng Wang, Zhongyu **e, Rui Yang, **teng Li… in Stem Cell Research & Therapy (2019)

Article

lncRNA-mRNA expression profiles and functional networks of mesenchymal stromal cells involved in monocyte regulation

The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating t...

Ming Li, Zhongyu **e, Zhaopeng Cai, Fang Su, Guan Zheng… in Stem Cell Research & Therapy (2019)

Article

Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment

The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic...

Guan Zheng, Zhongyu **e, Peng Wang, **teng Li, Ming Li… in Cell Death & Disease (2019)

Article

Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis

Ankylosing spondylitis (AS) is a common inflammatory autoimmune disease, characterized by pathological osteogenesis. Mesenchymal stem cells (MSCs), as the main source of osteoblasts, participate in bone remode...

Wenjie Liu, Peng Wang, Zhongyu **e, Shan Wang, Mengjun Ma… in Cell Death & Disease (2019)

Article

Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis

Crohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising ther...

Yuan Feng, Yan Liao, Weijun Huang, **ngqiang Lai, **g Luo, Cong Du… in Cell Death & Disease (2018)

Article

The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Mesenchymal stem cells (MSCs) are important pluripotent stem cells and a major source of adipocytes in the body. However, the mechanism of adipogenic differentiation has not yet been completely elucidated. In ...

Ming Li, Zhongyu **e, Peng Wang, **teng Li, Wenjie Liu, Su’an Tang… in Cell Death & Disease (2018)

Article

Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stro...

Zhongyu **e, Su’an Tang, Guiwen Ye, Peng Wang, **teng Li… in Stem Cell Research & Therapy (2018)