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  1. Article

    Open Access

    RNF141 interacts with KRAS to promote colorectal cancer progression

    RING finger proteins (RNFs) play a critical role in cancer initiation and progression. RNF141 is a member of RNFs family; however, its clinical significance, roles, and mechanism in colorectal cancer (CRC) rem...

    Jiuna Zhang, **aoyu Jiang, Jie Yin, Shiying Dou, **aoli **e, Ting Liu… in Oncogene (2021)

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  2. Article

    Open Access

    Targeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance

    Huanmin Niu, Lilin Qian, Yanhai Luo, Fang Wang… in Signal Transduction and Targeted Therapy (2021)

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  3. No Access

    Article

    Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate

    Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biologi...

    Yongfeng He, Daniel T. Johnson, Julie S. Yang, Huiqing Wu, Sungyong You… in Oncogene (2019)

  4. Article

    Open Access

    Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab

    Anterior gradient 2 (AGR2), a protein belonging to the protein disulfide isomerase (PDI) family, is overexpressed in multiple cancers and promotes angiogenesis to drive cancer progression. The mechanisms contr...

    Dawei Wang, Qingqing Xu, Quan Yuan, Mengqi Jia, Huanmin Niu, **aofei Liu… in Oncogene (2019)

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  5. No Access

    Article

    Androgen signaling is essential for development of prostate cancer initiated from prostatic basal cells

    Emerging evidence has shown that both prostatic basal and luminal cells are able to initiate oncogenic transformation. However, despite the diversity of tumor-initiating cells, most prostate cancer cells expre...

    Yongfeng He, Erika Hooker, Eun-Jeong Yu, Gerald R. Cunha, Lan Liao, Jianming Xu… in Oncogene (2019)

  6. No Access

    Article

    An hsRPB4/7-dependent yeast assay for trans-activation by the EWS oncogene

    Chromosomal fusions of the N-terminal region of the Ewings Sarcoma Oncogene (EWS-Activation-Domain, EAD) to the DNA-binding domains of a variety of cellular transcription factors, produce oncogenic proteins (EWS-...

    Huiqing Zhou, Kevin AW Lee in Oncogene (2001)