23 Result(s)

Article

Harmonemia: a universal strategy for flow cytometry immunophenoty**—A European LeukemiaNet WP10 study

F Lacombe, E Bernal, D Bloxham, S Couzens, M G D Porta, U Johansson, W Kern… in Leukemia (2016)

Article

Immunophenoty** of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

The European LeukemiaNet (ELN), workpackage 10 (WP10) was designed to deal with diagnosis matters using morphology and immunophenoty**. This group aimed at establishing a consensus on the required reagents f...

M C Béné, T Nebe, P Bettelheim, B Buldini, H Bumbea, W Kern, F Lacombe, P Lemez… in Leukemia (2011)

Article

Early clearance of peripheral blasts measured by flow cytometry during the first week of AML induction therapy as a new independent prognostic factor: a GOELAMS study

An early appreciation of treatment efficacy could be very useful in acute myeloblastic leukemia (AML), and a prognostic value has been suggested for the morphological assessment of decrease in blasts during in...

F Lacombe, C Arnoulet, M Maynadié, E Lippert, I Luquet, A Pigneux, N Vey… in Leukemia (2009)

Article

Discriminant function analysis as decision support system for the diagnosis of acute leukemia with a minimal four color screening panel and multiparameter flow cytometry immunophenoty**

Despite several recommendations for standardization of multiparameter flow cytometry (MFC) the number, specificity and combinations of reagents used by diagnostic laboratories for the diagnosis and classificat...

R Ratei, L Karawajew, F Lacombe, K Jagoda, G D Poeta, J Kraan, M De Santiago… in Leukemia (2007)

Article

Charon's size and an upper limit on its atmosphere from a stellar occultation

Stellar occultations, when a Solar System object passes between us and a star and blocks its light, are eagerly awaited by astronomers as they provide a chance to make measurements that are not normally possib...

B. Sicardy, A. Bellucci, E. Gendron, F. Lacombe, S. Lacour, J. Lecacheux… in Nature (2006)

Article

Near-infrared flares from accreting gas around the supermassive black hole at the Galactic Centre

Recent measurements of stellar orbits^1,2,3 provide compelling evidence that the compact radio source Sagittarius A* (refs 4, 5) at the Galactic Centre is a 3.6-million-solar-mass black hole. Sgr A* is remarkably ...

R. Genzel, R. Schödel, T. Ott, A. Eckart, T. Alexander, F. Lacombe, D. Rouan… in Nature (2003)

Article

Large changes in Pluto's atmosphere as revealed by recent stellar occultations

Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation e...

B. Sicardy, T. Widemann, E. Lellouch, C. Veillet, J.-C. Cuillandre, F. Colas… in Nature (2003)

Article

A star in a 15.2-year orbit around the supermassive black hole at the centre of the Milky Way

Many galaxies are thought to have supermassive black holes at their centres¹—more than a million times the mass of the Sun. Measurements of stellar velocities^2,3,4,5,6,7 and the discovery of variable X-ray emissi...

R. Schödel, T. Ott, R. Genzel, R. Hofmann, M. Lehnert, A. Eckart, N. Mouawad… in Nature (2002)

Article

Resistance to daunorubicin-induced apoptosis is not completely reversed in CML blast cells by STI571

The leukemogenic property of BCR-ABL in chronic myeloid leukemia (CML) is critically dependent on its protein tyrosine kinase activity. STI571 inhibits the BCR-ABL kinase activity, the growth and the viability...

R Tabrizi, FX Mahon, P Cony Makhoul, V Lagarde, F Lacombe, P Berthaud, JV Melo… in Leukemia (2002)

Article

Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis

Ceramide can induce apoptosis through a caspase independent pathway. Bax has been described as able to kill cells in the absence of caspase activity, therefore we measured Bax in situ during ceramide-induced apop...

M.A. Belaud-Rotureau, N. Leducq, F. Macouillard Poulletier de Gannes… in Apoptosis (2000)

Article

Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment

Anthracyclines trigger an apoptotic cell death but their molecular targets are not totally explored. We investigated the apoptotic response of blast cells and lymphocytes from medullary samples of 31 de novo acut...

M-A Belaud-Rotureau, F Durrieu, G Labroille, F Lacombe, O Fitoussi, P Agape… in Leukemia (2000)

Article

Dilatancy and friction in sheared granular media

We introduce a simple model to describe the frictional properties of granular media under shear. We model the friction force in terms of the horizontal velocity and the verti...

F. Lacombe, S. Zapperi, H.J. Herrmann in The European Physical Journal E (2000)

Article

Factors influencing haemopoietic recovery following chemotherapy-mobilised autologous peripheral blood progenitor cell transplantation for haematological malignancies: a retrospective analysis of a 10-year single institution experience

We retrospectively analysed the factors that influenced rate of haemopoietic recovery (HR) in 243 patients after transplantation with chemotherapy-mobilised autologous peripheral blood progenitor cells (PBPC)....

RM Lowenthal, C Fabères, G Marit, JM Boiron, P Cony-Makhoul… in Bone Marrow Transplantation (1998)

Article

Rapid analysis and efficient selection of human transduced primitive hematopoietic cells using the humanized S65T green fluorescent protein

We have developed an efficient and rapid method to analyze transduction in human hematopoietic cells and to select them. We constructed two retroviral vectors using the recombinant humanized S65T green fluores...

F Mazurier, F Moreau-Gaudry, V Maguer-Satta, S Salesse… in Gene Therapy (1998)

Article

Adaptive Optics on a 3.6-Meter Telescope. The ADONIS System.

ADONIS is an adaptive optics (AO) user friendly instrument offered to the European astronomical community on the ESO 3.6-m telescope at La Silla. It is an upgraded version of COME-ON-PLUS, the VLT AO prototype...

J.-L. Beuzit, L. Demailly, E. Gendron, P. Gigan, F. Lacombe… in Experimental Astronomy (1997)

Article

Flow cytometry CD45 gating for immunophenoty** of acute myeloid leukemia

A flow cytometry method has been introduced into the routine investigation of whole bone marrow samples following red blood cell lysis on the basis of a primary CD45/side scatter (SSC) gating procedure. Blast ...

F Lacombe, F Durrieu, A Briais, P Dumain, F Belloc, E Bascans, J Reiffers… in Leukemia (1997)

Article

Flow cytometry study of cell cycle, apoptosis and drug resistance in acute leukemia

The response to therapy of leukemic cells is largely determined by their capacity of proliferation and apoptosis in presence of the administered drugs. We describe here the main markers used in flow cytometry ...

F. Lacombe, F. Belloc in Hematology and Cell Therapy (1996)

Article

Posters

T. Török, A. Kardos, L. Rudas, D. Paprika, A. McLuckie… in Intensive Care Medicine (1996)

Article

First results obtained with DENIS

We briefly report on the first astronomical results obtained with the DENIS camera at the ESO 1 meter telescope.

E. Copet, B. De Batz, N. Epchtein, P. Fouqué, F. Lacombe… in Astrophysics and Space Science (1994)