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Comparing neoadjuvant therapy followed by local excision to total mesorectal excision in the treatment of early stage rectal cancer: a systematic review and meta-analysis of randomised clinical trials
Total mesorectal excision (TME) is the standard-of-care in early, clinical stage (cT2-3 N0 M0) rectal cancer. Local excision (LE) may be an alternative after adequate response to neoadjuvant therapy (NAT), wit...
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Article
Right Colectomy with Intracorporeal Anastomosis: A European Multicenter Propensity Score Matching Retrospective Study of Robotic Versus Laparoscopic Procedures
This study aimed to compare the short- and long-term outcomes of robotic (RRC-IA) versus laparoscopic (LRC-IA) right colectomy with intracorporeal anastomosis using a propensity score matching (PSM) analysis b...
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Open AccessThe therapeutic and prognostic implications of immunobiology in colorectal cancer: a review
Colorectal cancer represents the second leading cause of cancer-related death worldwide. The therapeutic field of immuno-oncology has rapidly gained momentum, with strikingly promising results observed in clin...
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Article
Open AccessEmergency surgery for splenic flexure cancer: results of the SFC Study Group database
The effectiveness of surgical treatment for splenic flexure carcinomas (SFCs) in emergency settings remains unexplored. This study aims to compare the perioperative and long-term outcomes of different alternat...
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Anastomotic leak risk in complete responders to neoadjuvant therapy for rectal cancer: a systematic review
The oncological benefits of achieving a complete pathological response following neoadjuvant chemoradiotherapy for rectal cancer are well defined. How a pathological response affects anastomotic healing or lea...
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Article
Evidence-based treatment strategies for acute diverticulitis
Diverticular disease is a common acquired condition of the lower gastrointestinal tract that may be associated with significant morbidity. The term encompasses a spectrum of pathological processes with varying...
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Extended right colectomy, left colectomy, or segmental left colectomy for splenic flexure carcinomas: a European multicenter propensity score matching analysis
The surgical resection of the splenic flexure carcinoma (SFC) is challenging and the optimal surgical procedure for SFCs remains a matter of debate. The present study aimed to compare in a multicenter European...
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Article
A meta-analysis of carbon dioxide versus room air insufflation on patient comfort and key performance indicators at colonoscopy
Carbon dioxide (CO2) has been used as an alternative to air insufflation at endoscopy with good results; however, uptake of the technique has been poor, possibly due to perceived lack of outcome equivalency. This...
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Article
Meta-analysis of early bowel resection versus initial medical therapy in patient's with ileocolonic Crohn's disease
Early bowel resection (EBR) in ileocolonic Crohn’s disease (CD) may be associated with more durable remission compared with initial medical therapy (IMT) even when biologic therapy is included.
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Concise Commentary: Pocketing the Difference—Genetics and the Changing Paradigms of Diverticulitis Management
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The sentinel stent? A systematic review of the role of prophylactic ureteric stenting prior to colorectal resections
‘Prophylactic’ ureteric stents potentially reduce rates, and facilitate intraoperative recognition, of iatrogenic ureteric injury (IUI) during colorectal resections. A lack of consensus surrounds the risk–bene...
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Article
Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer
A variety of inflammatory scoring systems and their prognostic value have been reported in many solid organ cancers. This study aimed to examine the association between the systemic and local inflammatory resp...
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Article
Orphan Nuclear Receptors in Colorectal Cancer
Colorectal cancer is one of the most common cancers worldwide, with an overall increased incidence annually. Despite improvements in treatment and surveillance, almost 50% develop recurrent and/or distant dise...
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Response to Letter to the Editor
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Exenterative Surgery for Advanced Prostate Cancer
The incidence of locally advanced prostate cancer has decreased in the last few decades since the introduction of screening programmes. Despite earlier detection and treatment, there is still a proportion of ...
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Article
Stumped; the Achilles of Laparoscopic Appendectomy
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Mesocolic plane surgery: a reliable benchmark of surgical excellence?
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Estrogen and its role in gastrointestinal health and disease
While the concept of a role of estrogen in gastrointestinal (in particular, colonic) malignancy has generated excitement in recent years, no review has examined the role of this potent and omnipresent steroid ...
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Complete Mesocolic Excision—A Marker of Surgical Quality?
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The Omentum: Anatomical, Metabolic, and Surgical Aspects
The omentum is acknowledged to have diverse functions in the pathophysiology of intra-abdominal disease. Its angiogenic properties act as a natural defense mechanism in peritonitis and intra-abdominal sepsis. ...