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Article
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples
The B-cell lymphoma-2 (Bcl-2) family contains six antiapoptotic members, each with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3) helices bind. This binding quenches apoptotic signals from activat...
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Article
Humanin peptide suppresses apoptosis by interfering with Bax activation
Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases1. Bax resides in an inactive state in the cytosol of many cells. ...
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Article
Dependence of permeability transition pore opening and cytochrome C release from mitochondria on mitochondria energetic status
The dependence of Ca2+-induced permeability transition pore (PTP) opening and cytochrome c (Cyt. c) release from mitochondria on mitochondria energetic status was investigated. Results of test the PTP opening and...
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Article
Study on the relationship between calcium-induced calcium release from mitochondria and PTP opening
The permeability transition pore (PTP) is central for mitochondria function. PTP either open in low-conductance state to carry out mCICR (Ca2+-induced Ca2+ release from mitochondria) and play roles in cell phsyio...