8 Result(s)

Article

A novel mode of RBD-protein recognition in the Y14–Mago complex

Y14 and Mago are conserved eukaryotic proteins that associate with spliced mRNAs in the nucleus and remain associated at exon junctions during and after nuclear export. In the cytoplasm, Y14 is involved in mRN...

Sébastien Fribourg, David Gatfield… in Nature Structural & Molecular Biology (2003)

Article

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte^1,2. This localization requires several trans-acting factors, inc...

Isabel M. Palacios, David Gatfield, Daniel St Johnston, Elisa Izaurralde in Nature (2004)

Article

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

In eukaryotic cells, messenger RNAs harbouring premature termination codons (PTCs) are rapidly degraded by a conserved post-transcriptional mechanism referred to as nonsense-mediated mRNA decay (NMD)^1,2, which pr...

David Gatfield, Elisa Izaurralde in Nature (2004)

Article

Barriers to progress or windows of opportunity? A study in career path map** in the maritime industries

The objective of the study was to provide, through a series of interviews with key personnel from a range of European Member States, an overview of the following:

Article

Transcriptome and translatome co-evolution in mammals

Gene-expression programs define shared and species-specific phenotypes, but their evolution remains largely uncharacterized beyond the transcriptome layer¹. Here we report an analysis of the co-evolution of trans...

Zhong-Yi Wang, Evgeny Leushkin, Angélica Liechti, Svetlana Ovchinnikova… in Nature (2020)