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A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus
Microalbuminuria is considered the first clinical sign of kidney dysfunction and is associated with a poor renal and cardiovascular prognosis in type 2 diabetes. Detection of patients who are prone to develop ...
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Open AccessHigh serum potassium levels after losartan can reflect more severe renal disease. Reply to Gonçalves AR, El Nahas AM [letter]
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Open AccessErratum to: Increased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
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Open AccessIncreased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
To assess the effect of an angiotensin receptor blocker (ARB) on serum potassium and the effect of a serum potassium change on renal outcomes in patients with type 2 diabetes and nephropathy.
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Renal failure induces telomere shortening in the rat heart
BackgroundRenal failure aggravates pathological cardiac remodelling induced by myocardial infarction (MI). Cardiac remodelling is associated with telomere shortening, a marker for biological ageing. We investigat...
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Adverse effects of left ventricular hypertrophy in the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study
We explored the impact of baseline left ventricular hypertrophy (LVH) and losartan treatment on renal and cardiovascular (CV) events in 1,513 patients from the Reduction of Endpoints in NIDDM with the Angioten...
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40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Recombinant Semliki Forest virus as a vector system for fast and selective in vivo gene delivery into balloon-injured rat aorta
Previously, we demonstrated that recombinant Semliki Forest virus (SFV) vector rapidly and selectively transfers genes into cultured vascular smooth muscle cells (VSMC), leaving endothelial cells (EC) unaffect...
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35th Annual Meeting of the European Association for the Study of Diabetes
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Pharmacokinetics and pharmacodynamics of candesartan cilexetil in patients with normal to severely impaired renal function
Objective: We studied the pharmacokinetics and pharmacodynamics of single and multiple doses of candesartan cilexetil 8 mg per day in hypertensive patients with different degrees of rena...
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ACE inhibitors and proteinuria
This review discusses the clinical consequences of uninary protein loss and the effects of inhibitors of the angiotensin converting enzyme (ACE) on this clinical finding. Proteinuria appears to be an important...
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Abstracts of papers and posters
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Abstracts of papers and posters Meeting on Pharmaceutical Sciences
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Abstracts of papers
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Pharmacological zero for electromagnetic renal blood flow measurement
Measurement of blood flow in chronically instrumented laboratory animals using electromagnetic flow probes depends on a reference “zero flow” value. The latter is usually obtained by mechanical vessel occlusio...
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Blood pressure response to enalaprilic acid in essential hypertension: Dose-response and effect of pre-treatment with furosemide
Enalaprilic acid (MK 422), the active metabolite of enalapril, has recently become available for intravenous administration. In order to establish the proper dose for rapid blood pressure reduction, 9 patients...
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Flowering of Xanthium under Long-Day Conditions
EFFORTS to induce flowering in the short-day plant Xanthium pensylvanicum under long-day conditions have consistently failed up to now. From numerous reports it has been concluded that for flower induction a shor...