18 Result(s)
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Article
D. L. Thomas
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Article
Open AccessNon-Invasive MRI of Blood–Cerebrospinal Fluid Barrier Function
The blood–cerebrospinal fluid barrier (BCSFB) is a highly dynamic transport interface that serves brain homeostasis. To date, however, understanding of its role in brain development and pathology has been hind...
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Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections
Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18). Hepatitis C virus (HCV) and human im...
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Open AccessDisrupted habenula function in major depression
The habenula is a small, evolutionarily conserved brain structure that plays a central role in aversive processing and is hypothesised to be hyperactive in depression, contributing to the generation of symptom...
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Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis
The host genetic basis of mixed cryoglobulin vasculitis is not well understood and has not been studied in large cohorts. A genome-wide association study was conducted among 356 hepatitis C virus (HCV) RNA-pos...
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Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descent
Hepatitis C virus (HCV) infects an estimated 3% of the global population with the majority of individuals (75–85%) failing to clear the virus without treatment, leading to chronic liver disease. Individuals of...
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Hip bone geometry in HIV/HCV-co-infected men and healthy controls
People with both HIV and hepatitis C are more likely than those with HIV alone to have wrist, hip, and spine fractures. We compared hip strength between HIV/HCV-co-infected men and healthy men and found that H...
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An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes
Recombinant herpes simplex virus type 1 (rHSV)-assisted recombinant adeno-associated virus (rAAV) vector production provides a highly efficient and scalable method for manufacture of clinical grade rAAV vector...
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Evaluation of on-farm irrigation applications using the simulation model EPIC
An understanding of water needs in agriculture is a critical input in resolving the water resource issues that confront many southeastern and other US states. The objective of this study was to evaluate on-far...
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Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance
Hepatitis C virus (HCV) is an infectious blood-borne pathogen that usually persists as a chronic infection. However, approximately 15% of the time, patients can clear the virus, indicating that host difference...
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Predicting Cotton Lint Yield Maps from Aerial Photographs
It is generally accepted that aerial images of growing crops provide spatial and temporal information about crop growth conditions and may even be indicative of crop yield. The focus of this study was to devel...
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An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection
The cytokine tumor necrosis factor alpha (TNF-α) is important in generating an immune response against a hepatitis C virus (HCV) infection. The functions of TNF-α may be altered by single-nucleotide polymorphi...
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MICA and recovery from hepatitis C virus and hepatitis B virus infections
The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized t...
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A vectorcardiograph for assessing implanted cardiac pacemakers
A pacemaker vectorcardiograph for the assessment of all makes and types of implanted cardiac pacemaker is described. Simultaneous measurement on conventional limb leads is employed and direct display on an osc...
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Improvements in the technique of assessing implanted cardiac pacemakers
Over 250 pacemaker patients currently attend pacemaker clinics in three Glasgow hospitals. Since 1968, the pacemaker frontal-plane vector technique has been used at these clinics along with other investigation...
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A pacemaker digital electrocardiograph for accurate measurements of pacemaker pulse amplitude, width and rate in the assessment of implanted cardiac pacemakers
During the past 8 yr over 170 patients in the Glasgow area have received cardiac pacemaker implants. All such patients attend pacemaker clinics at which both clinical and electronic examinations are carried ou...
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A pacemaker digital electrocardiograph for accurate assessment of implanted cardiac pacemakers
During the past 8 yr over 170 patients in the Glasgow area have received cardiac pacemaker implants. All such patients attend pacemaker clinics at which both clinical and electronic examinations are carried ou...
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Article
An electrically propelled vehicle for physically handicapped children
An electrically propelled vehicle with joystick control has been developed to give more independence to children who lack functional limbs. The joystick has two distinct actions: smooth control of forward and ...
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The angular distribution of the photoproduction of positive pions from hydrogen by 187 MeV γ-rays
The differential cross-section for π+ photoproduction from hydrogen by γ-rays of laboratory energy 187 MeV has been measured at four angles. Two identical counter systems, designed to detect low energy pions unam...
