184 Result(s)
-
Article
Open AccessCarbon and nitrogen stable isotope analyses of mammal bone fossils from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River, China
Based on AMS 14C dating data, carbon and nitrogen isotope analyses were conducted on mammal bone collagen of deer, cattle and pigs from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River. ...
-
Article
Open AccessTranscription factor IRF8 directs a silencing programme for TH17 cell differentiation
TH17 cells are recognized as a unique subset of T helper cells that have critical roles in the pathogenesis of autoimmunity and tissue inflammation. Although RORγt is necessary for the generation of TH17 cells, t...
-
Article
Open AccessHydrogen Bond Nanoscale Networks Showing Switchable Transport Performance
Hydrogen bond is a typical noncovalent bond with its strength only one-tenth of a general covalent bond. Because of its easiness to fracture and re-formation, materials based on hydrogen bonds can enable a rev...
-
Article
Open AccessIsolated nanographene crystals for nano-floating gate in charge trap** memory
Graphene exhibits unique electronic properties and its low dimensionality, structural robustness and high work-function make it very promising as the charge storage media for memory applications. Along with th...
-
Article
Open AccessDiets, eco-environments and seasonal variations recorded in the oxygen and carbon isotopic compositions of mammal tooth enamel from the Shunshanji site, Sihong County, Jiangsu Province, China
The carbon and oxygen isotopic compositions of the tooth enamel of mammals, including deer, wild pigs, buffaloes and domesticated pigs from the Shunshanji site, Sihong County, Jiangsu Province, China, were ana...
-
Article
Open AccessDual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans
The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been successfully used for genome editing in a variety of organisms. Here, we report the use of dual sgRNA-guided Cas9 nuclease to generate knockou...
-
Article
Open AccessHighly compressible 3D periodic graphene aerogel microlattices
Graphene is a two-dimensional material that offers a unique combination of low density, exceptional mechanical properties, large surface area and excellent electrical conductivity. Recent progress has produced...
-
Article
Open AccessReactive Liftoff of Crystalline Cellulose Particles
The condition of heat transfer to lignocellulosic biomass particles during thermal processing at high temperature (>400 °C) dramatically alters the yield and quality of renewable energy and fuels. In this work...
-
Article
Open AccessTryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to environmental toxicants, is increasingly recognized as a key player in embryogenesis and tumorigenesis. Here we sho...
-
Article
Open AccessAcrylamide toxic effects on mouse oocyte quality and fertility in vivo
Acrylamide is an industrial chemical that has attracted considerable attention due to its presumed carcinogenic, neurotoxic and cytotoxic effects. In this study we investigated possible acrylamide reproductive...
-
Article
Correction: Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction
Nature Communications 6, Article number: 6072 (2015); Published 23 January 2015; Updated 8 July 2015 In the Discussion section of this Article, we inadvertently stated that ‘endogenous IL-27 signalling results...
-
Article
Open AccessStructural diversity in binary superlattices self-assembled from polymer-grafted nanocrystals
Multicomponent nanocrystal superlattices represent an interesting class of material that derives emergent properties from mesoscale structure, yet their programmability can be limited by the alkyl-chain-based ...
-
Article
Open AccessThe Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes
H3K9 methylation is an important histone modification that is correlated with gene transcription repression. The asymmetric H3K9 dimethylation (H3K9me2) pattern between paternal and maternal genomes is generat...
-
Article
Open AccessTuning the conductance of H2O@C60 by position of the encapsulated H2O
The change of conductance of single-molecule junction in response to various external stimuli is the fundamental mechanism for the single-molecule electronic devices with multiple functionalities. We propose t...
-
Article
Open AccessBoth diet and gene mutation induced obesity affect oocyte quality in mice
Obesity was shown to cause reproductive dysfunctions such as reduced conception, infertility and early pregnancy loss. However, the possible effects of obesity on oocyte quality are still not fully understood....
-
Article
Open AccessObject-based Encoding in Visual Working Memory: Evidence from Memory-driven Attentional Capture
Visual working memory (VWM) adopts a specific manner of object-based encoding (OBE) to extract perceptual information: Whenever one feature-dimension is selected for entry into VWM, the others are also extract...
-
Article
Open AccessOlfactory perception and behavioral effects of sex pheromone gland components in Helicoverpa armigera and Helicoverpa assulta
Two sympatric species Helicoverpa armigera and Helicoverpa assulta use (Z)-11-hexadecenal and (Z)-9-hexadecenal as sex pheromone components in reverse ratio. They also share several other pheromone gland componen...
-
Article
Open AccessSafety and Efficacy of Trastuzumab Emtansine in Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: a Meta-analysis
Advanced or metastatic breast cancer is an incurable disease with high mortality rate worldwide and about 20% of breast cancers overexpress and amplify the human epidermal growth factor receptor 2 (HER2). Achi...
-
Article
Open AccessSoil ionomic and enzymatic responses and correlations to fertilizations amended with and without organic fertilizer in long-term experiments
To investigate potential interactions between the soil ionome and enzyme activities affected by fertilization with or without organic fertilizer, soil samples were collected from four long-term experiments ove...
-
Article
Open AccessThe impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum
Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer’s disease (LOAD), based on recent genome wide association studies (GWAS). Ho...