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  1. Article

    Open Access

    CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA

    Modification of RNAs, particularly at the terminals, is critical for various essential cell processes; for example, uridylation is implicated in tumorigenesis, proliferation, stem cell maintenance, and immune ...

    Yun Wang, Chenchun Weng, **angyang Chen, Xufei Zhou, **nya Huang… in BMC Biology (2020)

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  2. No Access

    Article

    RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway

    A genetic screen in C. elegans identifies a suppressor of siRNA and a new subset of 22G-RNAs that act through the nuclear RNAi pathway to downregulate pre-rRNA under stress conditions.

    Xufei Zhou, Xuezhu Feng, Hui Mao, Mu Li, Fei Xu… in Nature Structural & Molecular Biology (2017)

  3. Article

    Open Access

    Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans

    The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been successfully used for genome editing in a variety of organisms. Here, we report the use of dual sgRNA-guided Cas9 nuclease to generate knockou...

    **angyang Chen, Fei Xu, Chengming Zhu, Jiaojiao Ji, Xufei Zhou… in Scientific Reports (2014)

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