46 Result(s)

Article

Using support vector classification for SAR of fentanyl derivatives

To discriminate between fentanyl derivatives with high and low activities.

Ning Dong, Wen-cong Lu, Nian-yi Chen, You-cheng Zhu… in Acta Pharmacologica Sinica (2005)

Article

Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells

To examine the effect of venom from the spider Macrothele raven on cell proliferation and cytotoxicity in human cervical carcinoma, HeLa cells.

Li Gao, Bao-en Shan, **g Chen, Jiang-hui Liu, Da-xiang Song… in Acta Pharmacologica Sinica (2005)

Article

Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients

To evaluate the effects of UDP-glucuronosyltransferases (UGTs) polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil (MMF) in Chinese renal transplant recipients.

**ao-chun **e, Jun Li, Hong-yang Wang, Hong-liang Li… in Acta Pharmacologica Sinica (2015)

Article

Antibiotic-impregnated cement spacer as definitive management for osteomyelitis

Osteomyelitis is a challenge for orthopaedic surgeons. There is a lack of scientific evidence to guide treatment. The purpose of this study was to report the clinical outcome of unplanned retention of antibiot...

Xu-Sheng Qiu, **n Zheng, Hong-fei Shi, Yan-cheng Zhu… in BMC Musculoskeletal Disorders (2015)

Article

Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance

Most gefitinib-treated patients with non-small cell lung cancer (NSCLC) would eventually develop resistance. Lysimachia capillipes (LC) capilliposide extracts from LC Hemsl. show both in vitro and in vivo anti-ca...

Shi-rong Zhang, Ya-si Xu, Er **, Lu-cheng Zhu, Bing **a… in Acta Pharmacologica Sinica (2017)

Article

Activity of temocillin and 15 other agents, including fosfomycin and colistin, against Enterobacteriaceae in Hong Kong

Limited data are available on temocillin susceptibilities in Enterobacteriaceae from Asian countries where antimicrobial resistance is prevalent. The in vitro activities of temocillin and 15 commonly used antimic...

Margaret Ip, Christopher K. Lai… in European Journal of Clinical Microbiology … (2017)

Article

Identification of high-risk plaque features in intracranial atherosclerosis: initial experience using a radiomic approach

To evaluate a quantitative radiomic approach based on high-resolution magnetic resonance imaging (HR-MRI) to differentiate acute/sub-acute symptomatic basilar artery plaque from asymptomatic plaque.

Zhang Shi, Chengcheng Zhu, Andrew J. Degnan, **a Tian, **g Li… in European Radiology (2018)

Article

Severity of heterotopic ossification in patients following surgery for hip fracture: a retrospective observational study

Heterotopic ossification (HO) is a relatively common complication following hip surgery treated with open reduction and internal fixation, total arthroplasty or hemiarthroplasty. Development of HO after hip su...

Daichi Hayashi, Elaine S. Gould, Corey Ho… in BMC Musculoskeletal Disorders (2019)

Article

Parallel comparison of fibroblast-like synoviocytes from the surgically removed hyperplastic synovial tissues of rheumatoid arthritis and osteoarthritis patients

Fibroblast-like synoviocytes (FLS) are essential cellular components in inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Despite the growing use of FLS isolated from OA an...

Wei Huang, Linlin Zhang, Chao Cheng, Wenshan Shan… in BMC Musculoskeletal Disorders (2019)

Article

Dexmedetomidine Protects Against Oxygen–Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway

Although there is an increment in stroke burden in the world, stroke therapeutic strategies are still extremely limited to a minority of patients. We previously demonstrated that dexmedetomidine (DEX) protects...

Chen Zhu, Quan Zhou, Cong Luo, Ying Chen in NeuroMolecular Medicine (2020)

Article

Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner

Shichao Huang, Yu’e Liu, Yanan Zhang, Ru Zhang… in Signal Transduction and Targeted Therapy (2020)

Article

Persistently higher serum sCD40L levels are associated with outcome in septic patients

Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD4...

Yingjian Liang, Chengrui Zhu, Yini Sun, Zhiliang Li, Liang Wang… in BMC Anesthesiology (2021)

Article

Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis

Dissecting cellulitis of the scalp is a primary scarring alopecia. Isotretinoin is commonly referenced in the literature as a treatment for dissecting cellulitis. The objective of this article was to conduct a...

William Guo, Chencan Zhu, Gregg Stevens, David Silverstein in Drugs in R&D (2021)

Article

Quantitative assessment of the effectiveness of joint measures led by Fangcang shelter hospitals in response to COVID-19 epidemic in Wuhan, China

To quantitatively evaluate the effectiveness of Fangcang shelter hospitals, designated hospitals, and the time interval from illness onset to diagnosis toward the prevention and control of the COVID-19 epidemic.

Hui Jiang, Pengfei Song, Siyi Wang, Shuangshuang Yin… in BMC Infectious Diseases (2021)

Article

Serum surfactant protein D in COVID-19 is elevated and correlated with disease severity

The serum surfactant protein D (SP-D) level is suggested to be a useful biomarker for acute lung injuries and acute respiratory distress syndrome. Whether the serum SP-D level could identify the severity of co...

Ming Tong, Ying **ong, Chen Zhu, Hong Xu, Qing Zheng, Yu Jiang… in BMC Infectious Diseases (2021)

Article

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Un...

Mingfu Tian, Weiyong Liu, **ang Li, Peiyi Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of prim...

Kun Xu, Runtian Wang, Hui **e, Longfei Hu, Cong Wang, Jiali Xu, Chengjun Zhu… in Oncogenesis (2021)

Article

Physicians’ knowledge, attitude, and prescribing behavior regarding stress ulcer prophylaxis in China: a multi-center study

Perioperative patients are at risk of develo** stress ulcers (SU), which can cause clinically important bleeding. Stress ulcer prophylaxis (SUP) is widely applied to the patients in Intensive care unit (ICU)...

**ao Xuan **ng, Chen Zhu, Yan Qi Chu, **ang Rong Bai, Ke Wang… in BMC Gastroenterology (2021)

Article

The effect of self-limiting on the prevention and control of the diffuse COVID-19 epidemic with delayed and temporal-spatial heterogeneous

The global spread of the novel coronavirus pneumonia is still continuing, and a new round of more serious outbreaks has even begun in some countries. In this context, this paper studies the dynamics of a type ...

Cheng-Cheng Zhu, Jiang Zhu in BMC Infectious Diseases (2021)

Article

A fresh look at the role of spiramycin in preventing a neglected disease: meta-analyses of observational studies

We aimed to investigate the effect of antepartum treatment with spiramycin with or without subsequent pyrimethamine–sulfonamide–folinic acid, compared to no treatment, on the rate of mother-to-child transmissi...

Jose G. Montoya, Katherine Laessig… in European Journal of Medical Research (2021)