7 Result(s)

Article

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo… in Signal Transduction and Targeted Therapy (2023)

Article

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Molecular oxygen (O₂) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological p...

Zhen Luo, Mingfu Tian, Ge Yang, Qiaoru Tan… in Signal Transduction and Targeted Therapy (2022)

Article

Author Correction: SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen… in Nature Communications (2021)

Article

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Un...

Mingfu Tian, Weiyong Liu, **ang Li, Peiyi Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19...

Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen… in Nature Communications (2021)

Article

Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes...

Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu… in BMC Biology (2020)

Article

Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion

Zika virus (ZIKV) infection is a public health emergency and host innate immunity is essential for the control of virus infection. The NLRP3 inflammasome plays a key role in host innate immune responses by act...

Wenbiao Wang, Geng Li, De Wu, Zhen Luo, Pan Pan, Mingfu Tian… in Nature Communications (2018)