77 Result(s)

Article

Mitosis and microtubule organizational changes in rice root-tip cells

The pattern of change of the microtubule cytoskeleton of the root-tip cells of rice during mitosis was studied using immunofluorescence technic and confocal laser scanning microscopy. All the major stages of c...

Shixiong Xu, Chungui Li, Cheng Zhu in Cell Research (1993)

Article

An EM algorithm for map** segregation distortion loci

Chromosomal region that causes distorted segregation ratios is referred to as segregation distortion locus (SDL). The distortion is caused either by differential representation of SDL genotypes in gametes befo...

Chengsong Zhu, Yuan-Ming Zhang in BMC Genetics (2007)

Article

Expressed sequence tags from larval gut of the European corn borer (Ostrinia nubilalis): Exploring candidate genes potentially involved in Bacillus thuringiensis toxicity and resistance

Lepidoptera represents more than 160,000 insect species which include some of the most devastating pests of crops, forests, and stored products. However, the genomic information on lepidopteran insects is very...

Chitvan Khajuria, Yu Cheng Zhu, Ming-Shun Chen, Lawrent L Buschman… in BMC Genomics (2009)

Article

Experience-based behavioral and chemosensory changes in the generalist insect herbivore Helicoverpa armigera exposed to two deterrent plant chemicals

Behavioral and electrophysiological responses of larvae of the polyphagous moth species Helicoverpa armigera to two plant-derived allelochemicals were studied, both in larvae that had been reared on a diet devoid...

Dongsheng Zhou, Joop J. A. van Loon, Chen-Zhu Wang in Journal of Comparative Physiology A (2010)

Article

New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus

Cheng-Zhu Wu, An Na Moon, Jae-Hyuk Jang, Dongho Lee… in The Journal of Antibiotics (2011)

Article

Engineering a zinc binding site into the de novo designed protein DS119 with a βαβ structure

Functional proteins designed de novo have potential application in chemical engineering, agriculture and healthcare. Metal binding sites are commonly used to incorporate functions. Based on a de novo designed pro...

Cheng Zhu, Changsheng Zhang, Huanhuan Liang, Luhua Lai in Protein & Cell (2011)

Article

Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity

Corticosteroid-binding globulin (CBG) is a high-affinity plasma protein that transports glucocorticoids and progesterone. Others and we have reported non-synonymous single nucleotide polymorphisms (SNPs) that ...

Yue Li, Liang Wu, **gHui Lei, Cheng Zhu, HongMei Wang… in Science China Life Sciences (2012)

Article

Erratum to: Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity

Yue Li, Liang Wu, **gHui Lei, Cheng Zhu, HongMei Wang… in Science China Life Sciences (2012)

Article

A vertex similarity-based framework to discover and rank orphan disease-related genes

A rare or orphan disease (OD) is any disease that affects a small percentage of the population. While opportunities now exist to accelerate progress toward understanding the basis for many more ODs, the priori...

Cheng Zhu, Akash Kushwaha, Kenneth Berman, Anil G Jegga in BMC Systems Biology (2012)

Article

Hepatitis B virus inhibits apolipoprotein A5 expression through its core gene

Hepatitis B virus (HBV) infection causes lipid metabolism disorders. Apolipoprotein A5 (ApoA5) is a new apolipoprotein family member that plays an important role in the regulation of lipid metabolism. The pres...

Chengliang Zhu, Guosheng Gao, Hui Song, Fengxia Xu… in Lipids in Health and Disease (2016)

Article

Promoting effect of hepatitis B virus on the expressoin of phospholipase A2 group IIA

Hepatitis B virus (HBV) infection causes acute and chronic liver disease, ultimately leading to the development of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Phospholipase A2 group IIA (PLA2G2A) ...

Chengliang Zhu, Hui Song, Bingzheng Shen, Long Wu, Fang Liu… in Lipids in Health and Disease (2017)

Article

MetaTopics: an integration tool to analyze microbial community profile by topic model

Deciphering taxonomical structures based on high dimensional sequencing data is still challenging in metagenomics study. Moreover, the common workflow processed in this field fails to identify microbial commun...

Jifang Yan, Guohui Chuai, Tao Qi, Fangyang Shao, Chi Zhou, Chenyu Zhu… in BMC Genomics (2017)

Article

A time series driven decomposed evolutionary optimization approach for reconstructing large-scale gene regulatory networks based on fuzzy cognitive maps

Reconstructing gene regulatory networks (GRNs) from expression data plays an important role in understanding the fundamental cellular processes and revealing the underlying relations among genes. Although many...

**g Liu, Yaxiong Chi, Chen Zhu, Yaochu ** in BMC Bioinformatics (2017)

Article

Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity

Poly(ADP-ribose) polymerases (PARPs) are ADP-ribosylating enzymes and play important roles in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, a p...

Juanjuan Wang, Chenggang Zhu, Dan Song, Ruiqi **a, Wenbo Yu… in Cell Death Discovery (2017)

Article

Quantitative reproducibility analysis for identifying reproducible targets from high-throughput experiments

High-throughput assays are widely used in biological research to select potential targets. One single high-throughput experiment can efficiently study a large number of candidates simultaneously, but is subjec...

Wenfei Zhang, Ying Liu, Mindy Zhang, Cheng Zhu, Yuefeng Lu in BMC Systems Biology (2017)

Article

Hepatitis B virus inhibits the in vivo and in vitro synthesis and secretion of apolipoprotein C3

Hepatitis B virus (HBV) infection in the body can damage liver cells and cause disorders in blood lipid metabolism. Apolipoprotein C3 (ApoC3) plays an important role in the regulation of lipid metabolism, but ...

Chengliang Zhu, Hengcheng Zhu, Hui Song, Limin Xu… in Lipids in Health and Disease (2017)

Article

Identification of drought-responsive miRNAs and physiological characterization of tea plant (Camellia sinensis L.) under drought stress

Drought stress is one of the major natural challenges in the main tea-producing regions of China. The tea plant (Camellia sinensis) is a traditional beverage plant whose growth status directly affects tea quality...

Yuqiong Guo, Shanshan Zhao, Chen Zhu, **aojun Chang, Chuan Yue… in BMC Plant Biology (2017)

Article

miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2

Pre-eclampsia is a pregnancy-related disease that may cause maternal, neonatal and fetal morbidity and mortality and exists in 3–5% of pregnancies worldwide. The discovery of dysregulated microRNAs and their r...

Liang Wu, Wen-yan Song, Ya **e, Lin-li Hu, **ao-man Hou, Rui Wang… in Cell Death & Disease (2018)

Article

Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells

OCT4A is well established as a master transcription factor for pluripotent stem cell (PSC) self-renewal and a pioneer factor for initiating somatic cell reprogramming, yet its presence and functionality in som...

Yanwen Zhou, **nyu Chen, Bo Kang, Shiqi She, **aobing Zhang… in Cell Death & Disease (2018)

Article

Subcellular stoichiogenomics reveal cell evolution and electrostatic interaction mechanisms in cytoskeleton

Eukaryotic cells contain a huge variety of internally specialized subcellular compartments. Stoichiogenomics aims to reveal patterns of elements usage in biological macromolecules. However, the stoichiogenomic...

Yu-Juan Zhang, Chengxu Zhu, Yiran Ding, Zheng-Wen Yan, Gong-Hua Li… in BMC Genomics (2018)