77 Result(s)

Article

Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation

Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and tumorigenesis. However, the mechanism of non-apoptotic action...

Chenchen Zhu, Fushun Fan, Chuan-Yuan Li, Yan **ong, **njian Liu in Cell Death & Disease (2024)

Article

Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis

The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism of the crosstalk between cells in the pathogen...

Yulin Wang, Ziyan Shen, Shaocong Mo, Han Zhang, **g Chen, Cheng Zhu… in Human Cell (2024)

Article

Arbuscular mycorrhizal fungi by inducing watermelon roots secretion phthalates, altering soil enzyme activity and bacterial community composition to alleviate the watermelon wilt

Long-term continuous crop** has resulted in the frequent occurrence of fusarium wilt of watermelon (Citrullus lanatus). AMF inoculation can alleviate the continuous crop** barrier and reduce the incidence of ...

Wei Li, Chengshang Zhu, Yulu Song, Yufan Yuan, Min Li, Yingkun Sun in BMC Plant Biology (2024)

Article

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...

**g Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang… in Cell Death & Disease (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

Correction: Roles of estrogen receptors during sexual reversal in pelodiscus sinensis

Guobin Chen, Tong Zhou, Jizeng Cao, **ang Li, Chengjun Zhu… in Molecular Biology Reports (2024)

Article

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in bo...

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang… in Cell Death & Disease (2024)

Article

Engineering the Tat-secretion pathway of Bacillus licheniformis for the secretion of cytoplasmic enzyme arginase

The industrial bacterium Bacillus licheniformis has long been used as a microbial factory for the production of enzymes due to its ability to secrete copious amounts of native extracellular proteins and its gener...

Yi Ji, Junliang Li, Yonglin Liang, Liang Li… in Applied Microbiology and Biotechnology (2024)

Article

Tumor microenvironment remodeling plus immunotherapy could be used in mesenchymal-like tumor with high tumor residual and drug resistant rate

Epithelial-mesenchymal transition (EMT) is a common process during tumor progression and is always related to residual tumor, drug resistance and immune suppression. However, considering the heterogeneity in E...

Shuai Shen, **ng Liu, Qing Guo, Qingyu Liang, Jianqi Wu… in Communications Biology (2023)

Article

Droplet-based single-cell joint profiling of histone modifications and transcriptomes

We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure...

Yang **e, Chenxu Zhu, Zhaoning Wang… in Nature Structural & Molecular Biology (2023)

Article

Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications

Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver dysfunctions are classified into acute and chronic diseases. Various insults, including viral infections, alcohol or d...

Qian Huai, Cheng Zhu, Xu Zhang, Hanren Dai, **aolei Li, Hua Wang in Cell & Bioscience (2023)

Article

DNA methylation-dependent epigenetic regulation of Verticillium dahliae virulence in plants

As a conserved epigenetic mark, DNA cytosine methylation, at the 5’ position (5-mC), plays important roles in multiple biological processes, including plant immunity. However, the involvement of DNA methylatio...

Yun-Ya Chen, Chen Zhu, Jian-Hua Zhao, Ting Liu, Feng Gao, Ying-Chao Zhang… in aBIOTECH (2023)

Article

Hydrogen peroxide mediates high-intensity blue light-induced hypocotyl phototropism of cotton seedlings

Phototropism is a classic adaptive growth response that helps plants to enhance light capture for photosynthesis. It was shown that hydrogen peroxide (H₂O₂) participates in the regulation of blue light-induced hy...

Qian-yi Lv, Qing-** Zhao, Chen Zhu, Meichen Ding, Fang-yuan Chu… in Stress Biology (2023)

Article

Bacterial coinfections contribute to severe COVID-19 in winter

Hui Fan, Li Zhou, **gjun Lv, Shimin Yang, Guozhong Chen, **n** Liu… in Cell Research (2023)

Article

Association of the time course of Chinese visceral adiposity index accumulation with cardiovascular events in patients with hypertension

The Chinese visceral adiposity index (CVAI), a simple surrogate measure of visceral fat, is significantly associated with cardiovascular disease (CVD) risk in the general population. This study aimed to evalua...

Yuntao Wu, Wenqi Xu, Lu Guo, Wenjuan Li, Lisha Zhang… in Lipids in Health and Disease (2023)

Article

Correction to: Effects of Lead and Cadmium Combined Heavy Metals on Liver Function and Lipid Metabolism in Mice

Huaguo Chen, Chengxiang Zhu, **n Zhou in Biological Trace Element Research (2023)

Article

Privacy-preserving integration of multiple institutional data for single-cell type identification with scPrivacy

The rapid accumulation of large-scale single-cell RNA-seq datasets from multiple institutions presents remarkable opportunities for automatically cell annotations through integrative analyses. However, the pri...

Shaoqi Chen, Bin Duan, Chenyu Zhu, Chen Tang, Shuguang Wang… in Science China Life Sciences (2023)

Article

Identification and characterization of CircRNA-associated CeRNA networks in moso bamboo under nitrogen stress

Nitrogen is a macronutrient element for plant growth and development. Circular RNAs (circRNAs) serve as pivotal regulators for the coordination between nutrient supply and plant demand. Moso bamboo (Phyllostachys...

Chenglei Zhu, Tingting Yuan, Kebin Yang, Yan Liu, Ying Li, Zhimin Gao in BMC Plant Biology (2023)

Article

A new biotechnology for in-planta gene editing and its application in promoting flavonoid biosynthesis in bamboo leaves

Bamboo is a perennial and renewable biomass forest resource and its leaf flavonoid is an antioxidant for biological and pharmacological research. The established genetic transformation and gene editing systems...

Huayu Sun, Sining Wang, Chenglei Zhu, Kebin Yang, Yan Liu, Zhimin Gao in Plant Methods (2023)

Article

Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer

SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying ...

Hailin Zou, Juan Luo, Yibo Guo, Tongyu Tong… in Cellular and Molecular Life Sciences (2023)