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Article
Open AccessEnhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
Photochemical internalisation (PCI) is a technique for releasing biologically active macromolecules from endocytic vesicles by light activation of a photosensitiser localised in the same vesicles of targeted c...
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Article
Open AccessNitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells
Cutaneous melanoma is one of the highly malignant human tumours, due to its tendency to generate early metastases and its resistance to classical chemotherapy. We recently demonstrated that pamidronate, a nitr...
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Article
Open AccessDecreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation
Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to i...