17 Result(s)

Article

High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia

We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. Expression of LPL mRNA as well as protein was highly res...

D Heintel, D Kienle, M Shehata, A Kröber, E Kroemer, I Schwarzinger… in Leukemia (2005)

Article

Prognostic significance of molecular staging by PCR-amplification of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma (DLBCL)

The prognostic value of the detection of peripheral blood (PB) and/or bone marrow (BM) involvement by polymerase chain reaction (PCR) amplification of rearranged immunoglobulin heavy chain (IgH) and immunoglob...

G Mitterbauer-Hohendanner, C Mannhalter, K Winkler, M Mitterbauer, C Skrabs… in Leukemia (2004)

Article

High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGV_H gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia

Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation of B-cells. We investigated the expression of AID mRNA by real-time polymerase chain reaction (PCR) in peripheral blood mononu...

D Heintel, E Kroemer, D Kienle, I Schwarzinger, A Gleiß, J Schwarzmeier… in Leukemia (2004)

Article

Diffuse large B-cell lymphomas with plasmablastic/plasmacytoid features are associated with TP53 deletions and poor clinical outcome

To define reproducible criteria for subgroups of diffuse large B-cell lymphomas (DLBCL), including lymphomas with plasmablastic/plasmacytoid features (PB/PC-Fs), we investigated 66 DLBCL; the samples were cate...

I Simonitsch-Klupp, I Hauser, G Ott, J Drach, J Ackermann, J Kaufmann… in Leukemia (2004)

Article

Treatment of HBV-carrying lymphoma patients with Rituximab and CHOP: a diagnostic and therapeutic challenge

C Skrabs, C Müller, H Agis, C Mannhalter, U Jäger in Leukemia (2002)

Article

Alternative end-joining in follicular lymphomas’ t(14;18) translocation

T(14;18) chromosomal translocation is assumed to result from illegitimate rearrangement between the BCL2 proto-oncogene and the IGH locus during the D_H to J_H joining phase of V(D)J recombination in early B cells....

R Marculescu, T Le, S Böcskör, G Mitterbauer, A Chott, C Mannhalter, U Jaeger… in Leukemia (2002)

Article

Long-term clinical and molecular remission after allogeneic stem cell transplantation (SCT) in patients with poor prognosis non-Hodgkin's lymphoma

From 1987 to 1999 35 patients with poor prognosis non-Hodgkin's lymphoma (NHL) underwent allogeneic stem cell transplantation (SCT) at the University Hospitals of Vienna and Graz. Initial biopsy specimens were...

M Mitterbauer, P Neumeister, P Kalhs, S Brugger, G Fischer, K Dieckmann… in Leukemia (2001)

Article

Treatment of leukemic relapse after allogeneic stem cell transplantation with cytotoreductive chemotherapy and/or immunotherapy or second transplants

We analyzed toxicity and efficacy of chemotherapy (CT) or second stem cell transplantation (SCT) and/or immunotherapy defined as stop of immunosuppression (IS) or donor leukocyte infusion (DLI) in 47 patients ...

F Keil, E Prinz, P Kalhs, K Lechner, K Moser, I Schwarzinger, U Jäger… in Leukemia (2001)

Article

Evaluation of a highly specific functional test for the detection of factor V Leiden

In the present study, a new functional test for the detection of increased resistance of coagulation factor V to degradation by activated protein C (factor V Leiden mutation) was evaluated. The STA-STACLOT APC...

P. Quehenberger, S. Handler, C. Mannhalter… in International Journal of Clinical and Labo… (2000)

Article

Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR

Twenty-seven patients with AML and MLL gene rearrangement were analyzed by a reverse transcriptase polymerase chain reaction (RT-PCR) for the MLL-AF9 translocation. The MLL-AF9 fusion transcript was detected in s...

G Mitterbauer, C Zimmer, C Fonatsch, OA Haas, R Thalhammer-Scherrer… in Leukemia (1999)

Article

Genetic fingerprinting in mouthwashes of patients after allogeneic bone marrow transplantation

Detection of chimerism by PCR analysis of short tandem repeats (STR) in blood samples of patients who received allogeneic bone marrow transplantation (BMT) has proved to be an important method for early detect...

G Endler, H Greinix, K Winkler, G Mitterbauer, C Mannhalter in Bone Marrow Transplantation (1999)

Article

Low transplant-related mortality in patients receiving unrelated donor marrow grafts for leukemia

Transplantation with unrelated donor (UD) marrow has been shown to potentially cure patients with leukemia. Between January 1991 and April 1998, 54 patients with leukemia have received an UD BMT at our institu...

P Kalhs, S Brugger, E Reiter, F Keil, G Fischer… in Bone Marrow Transplantation (1999)

Article

Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia

The WT1 gene is expressed in 73–100% of patients with acute myelogenous leukemia (AML) and is thought to play a role in maintaining the viability of leukemic cells. WT1 has been proposed as a marker for minima...

A Gaiger, D Schmid, G Heinze, B Linnerth, H Greinix, P Kalhs, K Tisljar… in Leukemia (1998)

Article

Hypofibrinogenemia in non-M3 acute myeloid leukemia. Incidence, clinical and laboratory characteristics and prognosis

Among 379 patients with AML with FAB type M1, 2 and M4–7 diagnosed between 1978 and 1997 in our institution, 19 (5%) had hypofibrinogenemia (HF), ie a fibrinogen level <180 mg/dl. compared to patients with nor...

A Weltermann, I Pabinger, K Geissler, U Jäger, H Gisslinger, P Knöbl… in Leukemia (1998)

Article

Leukemia-free survival and mortality in patients with refractory or relapsed acute leukemia given marrow transplants from sibling and unrelated donors

Between April 1982 and February 1997 39 patients (24 male, 15 female) with refractory acute leukemia and a median age of 31 years (19–51 years) received allogeneic marrow grafts from an HLA-identical sibling (n =...

HT Greinix, E Reiter, F Keil, G Fischer, K Lechner… in Bone Marrow Transplantation (1998)

Article

Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia

We examined the presence of WT1-specific mRNA in bone marrow samples of 125 patients with de novo acute myeloid leukemia at diagnosis by two-step RT-PCR. The sensitivity of the assay was 1:100 (first step) and 1:...

D Schmid, G Heinze, B Linnerth, K Tisljar, R Kusec, K Geissler, C Sillaber… in Leukemia (1997)