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Article
Open AccessAngiogenesis-associated pathways play critical roles in neonatal sepsis outcomes
Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human ...
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Article
Open AccessHuman in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen
Adjuvants can enhance vaccine immunogenicity, but their mechanism of action is often incompletely understood, hampering rapid applicability for pandemic vaccines. Herein, we characterized the cellular and mole...
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Article
Open AccessDevelopment of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination
Infection is the most common cause of mortality early in life, yet the broad potential of immunization is not fully realized in this vulnerable population. Most vaccines are administered during infancy and chi...
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Article
Open AccessmRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in old...
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Article
Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen
The burden of newborn infectious disease has long been recognized as the highest across the entire human life span. The precise underlying cause is unfortunately still far from clear. A substantial body of dat...
