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Article
Fine root dynamics, longevity, and canopy characteristics of cotton under varying water and nitrogen levels
This study was conducted to understand the effects of water and nitrogen (N) on net root productivity, root longevity, root length, and canopy characteristics of cotton (Gossypium hirsutum L.), and to quantify th...
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Article
Open AccessDeficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding
The role of intestine clock in energy homeostasis remains elusive. Here we show that mice with Bmal1 specifically deleted in the intestine (Bmal1iKO mice) have a normal phenotype on a chow diet. However, on a hig...
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Article
Open AccessDysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian regulation of epileptic seizures. We first s...
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Article
Open AccessBmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice
Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 defic...
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Article
Open AccessREV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis
The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here we show colon clock genes (including Rev-erbα) are dysregulated in mice with DSS-induced colitis. In turn, disruption of ...
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Article
Nanosuspensions Containing Oridonin/HP-β-Cyclodextrin Inclusion Complexes for Oral Bioavailability Enhancement via Improved Dissolution and Permeability
Chemotherapy via oral route of anticancer drugs offers much convenience and compliance to patients. However, oral chemotherapy has been challenged by limited absorption due to poor drug solubility and intestin...
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Article
Glucose-Based Mesoporous Carbon Nanospheres as Functional Carriers for Oral Delivery of Amphiphobic Raloxifene: Insights into the Bioavailability Enhancement and Lymphatic Transport
Oral therapy with raloxifene (RXF), an amphiphobic drug for remedy of the postmenopausal osteoporosis and estrogen-dependent breast cancer, is less effective due to its poor bioavailability (2% or so). This wo...
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Article
Erratum to: Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences
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Article
Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences
Andrographolide (AND) and two of its derivatives, deoxyandrographolide (DEO) and dehydroandrographolide (DEH), are widely used in clinical practice as anti-inflammatory agents. However, UDP-glucuronosyltransfe...
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Article
A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2)
The efflux transporter breast cancer resistance protein (BCRP/ABCG2) plays an important role in excretion of anionic drugs and metabolites including glucuronides in humans.
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Article
Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches
Catalytic selectivity of human UGT1A9, an important membrane-bound enzyme catalyzing glucuronidation of xenobiotics, was determined experimentally using 145 phenolics and analyzed by 3D-QSAR methods.
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Article
Magnetic tunability of fiber optical parametric oscillators with optical clock extraction
A 10 Gb/s all-optical clock extraction based on magnetically controllable fiber optical parametric oscillator (MC-FOPO) is demonstrated. The operation properties of the magnetic control unit, composed of a sol...
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Article
Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms
Glucuronidation is a major barrier to flavonoid bioavailability; understanding its regiospecificity and reaction kinetics would greatly enhance our ability to model and predict flavonoid disposition. We aimed ...
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Article
Simulation model of magneto-optic fiber Bragg gratings and its applications in Sagnac interferometers
According to the symmetry of transmission matrix for non-uniform magneto-optic fiber Bragg gratings (MFBGs), the simulation model of the non-uniform MFBGs with bidirectional injection of light has been present...
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Article
Ground effects on magnetooptic Bragg cells
Propagation equation of magnetostatic waves in an arbitrarily magnetized yttrium-iron-garnet/gadolinium-gallium-garnet waveguide coated with perfect metal planes is obtained using the method of the surface mag...
