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Article
Open AccessDeficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding
The role of intestine clock in energy homeostasis remains elusive. Here we show that mice with Bmal1 specifically deleted in the intestine (Bmal1iKO mice) have a normal phenotype on a chow diet. However, on a hig...
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Article
Open AccessDysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian regulation of epileptic seizures. We first s...
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Circadian Clock and CYP Metabolism
Cytochromes P450 (CYPs), a superfamily of hemoproteins, have monooxygenase activity and are involved in xenobiotic detoxification and lipid metabolism. Circadian clock is known to impact drug efficacy and toxi...
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Article
Open AccessBmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice
Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 defic...
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Article
Numerical simulations of the discontinuous progression of cerebral aneurysms based on fluid-structure interactions study
Investigations into the characteristics of hemodynamics will provide a better understanding of the pathology of cerebral aneurysms for clinicians. In this work, a steady state discontinuous-growth model of the...
