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Open AccessEffect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma
A novel somatostatin analogue, TT-232 (which inhibits the proliferation of various cell cultures and transplantable mouse tumours), was examined regarding its effect on human melanoma and lymphoma xenografts a...
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Article
Open AccessAntitumor effect of lysine-isopeptides
Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect. The designed compou...
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Article
Open AccessAntagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers
Insulin-like growth factors (IGFs) I and II are implicated in progression of various tumours including colorectal carcinomas. To interfere with the production of IGFs, we treated male nude mice bearing xenogra...
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Article
Protective effects of D-Trp6-luteinising hormone-releasing hormone microcapsules against cyclophosphamide-induced gonadotoxicity in female rats
The possible protective effect of an agonist of luteinising hormone-releasing hormone (LH-RH) against the ovarian damage caused by cyclophosphamide was investigated in rats. D-Trp6-LH-RH microcapsules were inj...
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Article
Studies on in vitro carcinogenesis
The incorporation of radioactive labelled Methylcholanthrene into CBA/T6T6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation cou...
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Article
A Transferable “Resistance Factor” from in vitro Cultured MDMS-Resistant Yoshida Sarcoma Cells
Cells of the methylene dimethanesulphonate-(MDMS)-resistant Yoshida sarcoma cell line contain a low molecular weight “resistance factor” which is present in the culture medium of these cells and may be utilize...
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Article
Über die geschwulsterzeugende Wirkung des Hydrazins
Die Autoren haben 34 weißen Mäusen intraperitoneal insgesamt 400 mg/kg Körpergewicht Hydrazin verabreicht. Zwischen dem 100. und 313. Versuchstag entstanden bei 13 Tieren Reticulosarkome und Leukämien (s. Tabe...
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Article
Neue experimentelle Angaben zur geschwulsterzeugenden Wirkung des Isonicotinsäurehydrazid (INH)
50 weißen Mäusen wurde Isonicotinsäurehydrazid in physiologischer Kochsalzlösung längere Zeit hindurch intraperitoneal in einer Gesamtmenge von 55 mg verabreicht. In 95–400 Tagen nach Versuchsbeginn traten bei...