3 Result(s)
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Article
Annelieke S. de Wit
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Article
Open AccessCircadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients
The anti-estrogen tamoxifen is characterized by a large variability in response, partly due to pharmacokinetic differences. We examined circadian variation in tamoxifen pharmacokinetics in mice and breast canc...
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Open AccessRelationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence
Circadian rhythms may influence the pharmacokinetics of drugs. This study aimed to elucidate whether the pharmacokinetics of the orally administered drug sunitinib are subject to circadian variation.
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Open AccessDNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metab...
