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Article
Open AccessModeling the limits of detection for antimicrobial resistance genes in agri-food samples: a comparative analysis of bioinformatics tools
Although the spread of antimicrobial resistance (AMR) through food and its production poses a significant concern, there is limited research on the prevalence of AMR bacteria in various agri-food products. Seq...
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Article
Open AccessTetanus in a vaccinated soil expert - a case report
Tetanus is a life-threatening vaccine-preventable disease found more commonly in tropical climates. It accounted for up to 60 deaths annually until the introduction of the tetanus toxoid. It is now rare in Can...
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Article
Correction: Association between pre‑treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis
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Article
Association between pre-treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis
Immune checkpoint inhibitors (ICIs) are a first-line treatment for various metastatic solid tumors. Pneumonitis is a potentially devastating complication of ICI treatment and a leading cause of ICI-related mor...
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Article
Open AccessCollateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance
The rapid emergence of antimicrobial resistance presents serious health challenges to the management of infectious diseases, a problem that is further exacerbated by slowing rates of antimicrobial drug discove...
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Article
Open AccessSpatial map** of mitochondrial networks and bioenergetics in lung cancer
Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells1. The mitochondria form highly organized networks, in which their outer and inner membrane structures define their bioen...
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Article
Long-term functional results of transvaginal anal sphincter repair for faecal incontinence; a retrospective case series
We report our experience with a transvaginal approach with overlap** anal sphincter repair. The aim of this cohort study was to evaluate long-term functional outcomes. Women who had undergone transvaginal an...
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Article
Open AccessCorrection to: Near-term climate risks and solar radiation modification: a roadmap approach for physical sciences research
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Article
Open AccessNear-term climate risks and sunlight reflection modification: a roadmap approach for physical sciences research
Current impacts and escalating risks of climate change require strong and decisive action to reduce greenhouse gas (GHG) emissions. They also highlight the urgency of research to enhance safety for human and n...
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Article
Open AccessExperiences and Perspectives of Patients with Non-HIV-Associated Lipodystrophies and Their Caregivers: A Qualitative Study
Lipodystrophy comprises a group of conditions characterized by loss of functional adipose tissue, resulting in severe metabolic complications and a complex range of symptoms.
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Article
Open AccessPost-gel polymerisation shrinkage profiling of polymer biomaterials using a chirped fibre Bragg grating
A strain profile measurement technique using a chirped fibre Bragg grating (CFBG) sensor by implementing an integration of differences (IOD) method is reported in this paper. Using the IOD method the spatial d...
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Article
Governing antimicrobial resistance: a narrative review of global governance mechanisms
Antimicrobial resistance (AMR), a central health challenge of the twenty first century, poses substantial population health risks, with deaths currently estimated to be around 700,000 per year globally. The in...
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Article
The effect of environmental heterogeneity on the fitness of antibiotic resistance mutations in Escherichia coli
Antimicrobial resistance (AMR) is widespread, with resistant pathogens found not only in the clinic but throughout the natural and built environments. It is unclear, however, to what extent AMR should be expec...
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Article
Open AccessCharacteristics and outcomes of antiretroviral-treated HIV-HBV co-infected patients in Canada
Hepatitis B (HBV) and Human Immunodeficiency Virus (HIV) share common risk factors for exposure. Co-infected patients have an increased liver-related mortality risk and may have accelerated HIV progression. Th...
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Article
Open AccessLipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment
Aberrant lipid accumulation is a hallmark of cancer known to contribute to its aggressiveness and malignancy. Emerging studies have demonstrated context-dependent changes in lipid metabolism during chemotherap...
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Article
Assessment of molecular detection of anaerobic ammonium-oxidizing (anammox) bacteria in different environmental samples using PCR primers based on 16S rRNA and functional genes
Eleven published PCR primer sets for detecting genes encoding 16S ribosomal RNA (rRNA), hydrazine oxidoreductase (HZO), cytochrome cd 1-containing nitrite reductase (NirS), and hydrazine s...
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Article
The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions
Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no ...
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Article
Using the ICF’s environmental factors framework to develop an item bank measuring built and natural environmental features affecting persons with disabilities
To develop a measure of natural environment and human-made change features (Chapter 2 of the international classification of functioning, disability, and health) and evaluate the influence of perceived barrier...
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Article
Open AccessHigh-quality genome assembly of channel catfish, Ictalurus punctatus
The channel catfish (Ictalurus punctatus), a species native to North America, is one of the most important commercial freshwater fish in the world, especially in the United States’ aquaculture industry. Since its...
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Article
Open AccessFish-T1K (Transcriptomes of 1,000 Fishes) Project: large-scale transcriptome data for fish evolution studies
Ray-finned fishes (Actinopterygii) represent more than 50 % of extant vertebrates and are of great evolutionary, ecologic and economic significance, but they are relatively underrepresented in ‘omics studies. ...
