22 Result(s)
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Article
Photoconductivity of [60]fullerene derivatives
Two [60]fullerene derivatives (compounds 1 and 2) have been synthesized. Their redox properties have been measured by cyclic voltammetry. The photoconductivities of poly(N-vinylcarbazole) (PVK) doped with [60]...
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Article
Fabrication and magnetic properties of Co nanowire arrays of different crystal structures
Co nanowire arrays of different crystal structures have been electrodeposited into self-assembled anodic aluminum oxide (AAO) templates by varying pH value of electrolyte. The XRD results show that crystal str...
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Article
Gene expression and molecular characterization of a thermostable trehalose phosphorylase fromThermoanaerobacter tengcongensis
A gene encoding the trehalose phosphorylase (TreP), which reversibly catalyzes trehalose degradation and synthesis from α-glucose-1-phosphate (α-Glc-1-P) and glucose, was cloned fromThermoanaerobacter tengcongens...
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Open AccessShort Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions
Protein interactions are essential for most cellular functions. Interactions mediated by domains that appear in a large number of proteins are of particular interest since they are expected to have an impact o...
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Article
Open AccessThe conservation pattern of short linear motifs is highly correlated with the function of interacting protein domains
Many well-represented domains recognize primary sequences usually less than 10 amino acids in length, called Short Linear Motifs (SLiMs). Accurate prediction of SLiMs has been difficult because they are short ...
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Article
Building the sequence map of the human pan-genome
Here we integrate the de novo assembly of an Asian and an African genome with the NCBI reference human genome, as a step toward constructing the human pan-genome. We identified ∼5 Mb of novel sequences not presen...
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Article
Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology
Mechanotransduction of sensory neurons is of great interest to the scientific community, especially in areas such as pain, neurobiology, cardiovascular homeostasis and mechanobiology. We describe a method to i...
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Article
Open AccessTranscriptional profiling by cDNA-AFLP analysis showed differential transcript abundance in response to water stress in Populus hopeiensis
Drought is one of the main environmental factors limiting tree growth and productivity of plantation forests worldwide. Populus hopeiensis Hu et Chow is one of the most important commercial plantation tree specie...
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Article
Open AccessPrecise measurement of stable (δ 88/86Sr) and radiogenic (87Sr/86Sr) strontium isotope ratios in geological standard reference materials using MC-ICP-MS
A new method for high-precision measurements of stable (δ 88/86Sr) and radiogenic (87Sr/86Sr) Sr isotope ratios was developed on the MC-ICP-MS using a standard-sample-standard bracketing protocol....
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Article
Metal-free porous nitrogen-doped carbon nanotubes for enhanced oxygen reduction and evolution reactions
Develo** efficient metal-free bi-functional electrocatalysts is required to reduce costs and improve the slow oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) kinetics in electrochemical s...
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Article
sCMOS noise-correction algorithm for microscopy images
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Article
Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress
Herein, Tudor-SN was identified as a DNA damage response (DDR)-related protein that plays important roles in the early stage of DDR. X-ray or laser irradiation could evoke the accumulation of Tudor-SN to DNA d...
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Article
A particle-filter framework for robust cryo-EM 3D reconstruction
Single-particle electron cryomicroscopy (cryo-EM) involves estimating a set of parameters for each particle image and reconstructing a 3D density map; robust algorithms with accurate parameter estimation are e...
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Open AccessHarnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production
Accumulation of high-value products in microalgae is not conducive with rapid cell growth, which is the potential conflict in microalgal production. Overcoming such conflict faces numerous challenges in compre...
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Open AccessNesfatin-1 protects H9c2 cardiomyocytes against cobalt chloride-induced hypoxic injury by modulating the MAPK and Notch1 signaling pathways
This study aimed to explore the effect of nesfatin-1 on cobalt chloride (CoCl2)-induced hypoxic injury in cardiomyocyte H9c2 cells.
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Open AccessComprehensive transcriptomic characterization reveals core genes and module associated with immunological changes via 1619 samples of brain glioma
Glioma is the most common primary malignant brain tumor with limited treatment options and poor prognosis. To investigate the potential relationships between transcriptional characteristics and clinical phenot...
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Article
Open AccessArginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform significant roles in the regulation o...
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Article
Open AccessA novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation
Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibite...
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Open AccessDeciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysis
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Open AccessVascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia
Vascular smooth muscle cell (VSMC) proliferation is the leading cause of vascular stenosis or restenosis. Therefore, investigating the molecular mechanisms and pivotal regulators of the proliferative VSMC phen...
