102 Result(s)
within
Life Sciences
Life Sciences, general
**yang Zhou
Article
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Article
Analysis of cytochrome P450 genes in silkworm genome (Bombyx mori)
We have searched the Bombyx mori genome for members of the major enzyme family, the Cytochrome P450s, which carry out multiple reactions to enable organisms to rid themselves of foreign compounds. As a result, 86...
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The Abiotic Formation of Hydrocarbons from Dissolved CO2 Under Hydrothermal Conditions with Cobalt-Bearing Magnetite
Conversion of CO2 to organic compounds in hydrothermal systems is important in understanding prebiotic chemical evolution leading to the origin of life. However, organic compounds with carbon number of more than ...
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Open AccessChloroplast genome sequencing analysis of Heterosigma akashiwo CCMP452 (West Atlantic) and NIES293 (West Pacific) strains
Heterokont algae form a monophyletic group within the stramenopile branch of the tree of life. These organisms display wide morphological diversity, ranging from minute unicells to massive, bladed forms. Surpr...
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NGF-dependent retrograde signaling: survival versus death
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An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector
Adenoviral vectors have shown great promise as vaccine carriers and in gene transfer to correct underlying genetic diseases. Traditionally, cstruction of adenoviral vectors is complex and time consuming. In th...
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A genome-scale shRNA resource for transgenic RNAi in Drosophila
Short hairpin RNAs, expressed from microRNA scaffold–containing vectors, efficiently silence gene expression in female germ cells as well as somatic cells in the fly. A genome-wide resource is being developed.
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Impact of bifunctional chelators on biological properties of 111In-labeled cyclic peptide RGD dimers
The present study describes the synthesis and biological evaluation of 111In(DOTA-3P-RGD2) (DOTA = 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid; 3P-RGD2 = PEG4-E[PEG4-c(RGDfK)]2; PEG4 = 15-amino-4,7,...
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Article
Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice
Gene expression can be regulated by chromatin modifiers, transcription factors and proteins that modulate DNA architecture. Among the latter, AT-hook transcription factors have emerged as multifaceted regulato...
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A transcription activator-like effector toolbox for genome engineering
Transcription activator-like effectors (TALEs) are a class of naturally occurring DNA-binding proteins found in the plant pathogen Xanthomonas sp. The DNA-binding domain of each TALE consists of tandem 34–amino a...
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Open AccessComparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation
Microsporidian Nosema bombycis has received much attention because the pébrine disease of domesticated silkworms results in great economic losses in the silkworm industry. So far, no effective treatment could be ...
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Open AccessSplice variants and promoter methylation status of the Bovine Vasa Homology (Bvh) gene may be involved in bull spermatogenesis
Vasa is a member of the DEAD-box protein family that plays an indispensable role in mammalian spermatogenesis, particularly during meiosis. Bovine vasa homology (Bvh) of Bos taurus has been reported, however, its...
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Open AccessAssessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing
Diamond–Blackfan anemia is a rare congenital red blood cell dysplasia that develops soon after birth. RPL11 mutations account for approximately 4.8% of human DBA cases with defective hematopoietic phenotypes. ...
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Open AccessDetection of copy number variations and their effects in Chinese bulls
Copy number variations (CNVs) are a main source of genomic structural variations underlying animal evolution and production traits. Here, with one pure-blooded Angus bull as reference, we describe a genome-wid...
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Open AccessCHD3 chromatin-remodeling factor PICKLE regulates floral transition partially via modulating LEAFY expression at the chromatin level in Arabidopsis
PICKLE (PKL), a putative CHD3 chromatin remodeling factor, has been suggested to be involved in multiple processes in Arabidopsis. Here, we confirmed the late-flowering phenotype ...
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Open AccessGenome-wide CNV analysis reveals variants associated with growth traits in Bos indicus
Apart from single nucleotide polymorphism (SNP), copy number variation (CNV) is another important type of genetic variation, which may affect growth traits and play key roles for the production of beef cattle....
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How China can enhance adoption of biotech crops
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Open AccessPlant pattern-recognition receptors controlling innate immunity
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Open AccessReduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression
As a major epigenetic component, DNA methylation plays important functions in individual development and various diseases. DNA methylation has been well studied in human and model organisms, but only limited d...
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Open AccessErratum to: Plant pattern-recognition receptors controlling innate immunity
Plants are exposed to numerous potential pathogenic microbes. To counter the threat, plants have evolved diverse patternrecognition receptors (PRRs), which are receptor kinases (RKs) and receptor proteins (RPs...
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Cell-penetrating peptides induce apoptosis and necrosis through specific mechanism and cause impairment of Na+–K+-ATPase and mitochondria
Cell-penetrating peptides (CPPs) are widely used in the development of various drug delivery systems because of their ability of penetrating plasma membrane. However, the safety of their application remains la...
