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Open AccessCorrection: Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats
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Open AccessExercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are commonly used in the management of type 2 diabetes mellitus (T2DM) and have been found to worsen the reduction of skeletal muscle mass in individuals with...
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Article
Open AccessThe plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)
Plants produce various plant secondary compounds (PSCs) to deter the foraging of herbivorous mammals. However, little is known about whether PSCs can reshape gut microbiota and promote gut homeostasis of hosts...
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Article
Open AccessAssociation study and expression analysis of CYP4A11 gene copy number variation in Chinese cattle
The identification of copy number variations (CNVs) allow us to explore genomic polymorphisms. In recent years, significant progress in understanding CNVs has been made in studies of human and animals, however...
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Article
Open AccessDetection of copy number variations and their effects in Chinese bulls
Copy number variations (CNVs) are a main source of genomic structural variations underlying animal evolution and production traits. Here, with one pure-blooded Angus bull as reference, we describe a genome-wid...
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Article
Copy number variations of MICAL-L2 sha** gene expression contribute to different phenotypes of cattle
Copy number variations (CNVs) recently have been recognized as an important source of genetic variability. Compelling evidence has indicated that CNVs are responsible for phenotypic traits by altering the cop...
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Article
Allelic Polymorphism Detected in the Bovine FTO Gene
Studies in humans have independently identified single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene associated with obesity in multiple populations. It was shown that FTO part...
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SNPs in the coding region of bovine MGAT2 gene are associated with body weight and weight gain
Monoacylglycerol acyltransferase 2 (MGAT2), as a candidate gene for quantitative traits, relates to dietary fat uptake, lipids synthesis and storage, which plays a major role in the absorption of dietary fat by c...
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Article
SNP discovery and haplotype analysis in the bovine PRKAA2 gene
The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a cellular fuel gauge that regulates metabolic pathways in glucose and fatty acid metabolism and protein ...
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Article
Polymorphisms in the promoter region of bovine PRKAB1 gene
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular and systemic energy balance. PRKAB1, the gene that encodes the β1 regulatory subunit of AMPK, has been shown to be highly ...
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Article
Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle
GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Association...
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Article
Single Nucleotide Polymorphisms and Haplotypic Diversity in the Bovine PRKAB1 Gene
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular and systemic energy balance. PRKAB1, the gene that encodes the β1 regulatory subunit of AMPK, has been shown to be highly ...
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Article
A novel missense (A79V) mutation of goat PROP1 gene and its association with production traits
As a paired class homeodomain transcription factor, mutations of PROP1 (Prophet of POU1F1) are responsible for deficiencies of GH, PRL, TSH, LH and FSH. Regarding mutations of GH, PRL, and POU1F1 genes significan...
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Article
The novel 5bp deletion polymorphism in the promoter region of bovine ACRP30 gene
ACRP30 gene was located nearby the QTL affecting the marbling, ribeye muscle area and fat thickness on the BAT1 in Angus. In this study, a 5bp deletion mutation within the bovine ACRP30 g...
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Article
Novel Polymorphism at the 3′ UTR of the Caprine Adiponectin Gene
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Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits
In this study, polymorphism in the bovine LEPR gene exon 4 was detected by PCR-SSCP and DNA sequencing methods in 653 individuals from five Chinese cattle breeds. Two haplotypes (M and N), three observed genotype...
