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  1. Article

    Open Access

    Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization

    Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast u...

    Ayele H. Negussie, Quirina M. B. de Ruiter, Hugh Britton… in Scientific Reports (2021)

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  2. Article

    Open Access

    Treatment with the IDO inhibitor INCB024360 increased lysis of human tumor cell targets by peptide-specific CTL

    Caroline Jochems, Anna Kwilas, Young-Seung Kim… in Journal for ImmunoTherapy of Cancer (2015)

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  3. No Access

    Article

    An overview of targeted alpha therapy

    The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-particles. Alpha particles are helium nuclei and are ~8,000 times larger than β−-particles (electrons). When emitted from radi...

    Young-Seung Kim, Martin W. Brechbiel in Tumor Biology (2012)

  4. No Access

    Article

    Impact of bifunctional chelators on biological properties of 111In-labeled cyclic peptide RGD dimers

    The present study describes the synthesis and biological evaluation of 111In(DOTA-3P-RGD2) (DOTA = 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid; 3P-RGD2 = PEG4-E[PEG4-c(RGDfK)]2; PEG4 = 15-amino-4,7,...

    Jiyun Shi, Young-Seung Kim, Sudipta Chakraborty, Yang Zhou, Fan Wang… in Amino Acids (2011)

  5. No Access

    Article

    99mTcO(MAG2-3G3-dimer): a new integrin αvβ3-targeted SPECT radiotracer with high tumor uptake and favorable pharmacokinetics

    This report presents the synthesis of a cyclic RGD dimer conjugate, MAG2-G3-E[G3-c(RGDfK)]2 (MAG2-3G3-dimer, G3 = Gly-Gly-Gly, MAG2 = S-benzoyl mercaptoacetylglycylglycyl), and evaluation of its 99mTc complex, 99...

    Jiyun Shi, Lijun Wang, Young-Seung Kim… in European Journal of Nuclear Medicine and M… (2009)