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Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular docking
Purpose: Zhizi-Bopi decoction (ZZBPD) is a classic herbal formula with wide clinical applications in treating liver diseases including hepatitis B. However, the mechanism needs to be elucidated.
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Article
Structure and stability analysis of antibacterial substance produced by selenium enriched Bacillus cereus BC1
Microorganisms can produce many antibiotics against bacteria and fungi, which have been used as a potential choice of new antibiotics. In this paper, we studied the characteristics of antibacterial substances by
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Article
Characterization and genomic analysis of a Demerecviridae phage SP76 with lytic multiple-serotypes of Salmonella
With the increase in antimicrobial resistance of Salmonella, phages have been paid more attention to as an alternative to antibiotics. In this study, a phage designated as SP76 was isolated from sewage. It can ly...
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Article
The effectiveness of extended binding affinity of prophage lysin PlyARI against Streptococcus suis infection
Streptococcus suis is an important zoonotic pathogen. An increase in multi-drug-resistant strains has led to poor performance of traditional antibiotic therapies. Thus, alternative antibacterial agents are urgent...
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Article
Efficient production of l-menthyl α-glucopyranoside from l-menthol via whole-cell biotransformation using recombinant Escherichia coli
l-Menthyl α-D-glucopyranoside (α-MenG) is a glycoside derivative of l-menthol with improved water-solubility and new flavor property as a food additive. α-MenG can be synthesized through biotransformation, but it...
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Article
Clinical Characteristics of Human Adenovirus Plastic Bronchitis in 10 Pediatric Cases: A Retrospective Study of Seven Years
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Article
Recombination of T4-like Phages and Its Activity against Pathogenic Escherichia coli in Planktonic and Biofilm Forms
The increasing emergence of multi-drug resistant Escherichia coli (E. coli) has become a global concern, primarily due to the limitation of antimicrobial treatment options. Phage therapy has been considered as a ...
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Article
Colorimetric detection of Hg2+ using gold nanoparticles synthesized by Trichosporon montevideense WIN
To investigate a simple, cost-effective and eco-friendly method for colorimetric detection of Hg2+ using gold nanoparticles (AuNPs) synthesized by Trichosporon montevideense WIN.
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Article
Role of nitric oxide and hydrogen sulfide in plant aluminum tolerance
As gasotransmitter, nitric oxide (NO) and hydrogen sulfide (H2S) are involved in the regulation of plant tolerance to abiotic stresses. Aluminum (Al) toxicity triggers synthesis of NO and H2S and seriously affect...
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Article
Isolation of a fungus Pencicillium sp. with zinc tolerance and its mechanism of resistance
A zinc (Zn)-tolerant fungus, designated BC109-2, was isolated from rhizosphere soil and was identified as Penicillium janthinellum BC109-2 based on ITS sequence analysis. To understand its Zn tolerance mechanisms...
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Article
Open AccessGenomic insights into temperature-dependent transcriptional responses of Kosmotoga olearia, a deep-biosphere bacterium that can grow from 20 to 79 °C
Temperature is one of the defining parameters of an ecological niche. Most organisms thrive within a temperature range that rarely exceeds ~30 °C, but the deep subsurface bacterium Kosmotoga olearia can grow over...
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Article
Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging
Secondary ion mass spectrometry, including nanoscale secondary ion mass spectrometry (NanoSIMS) and time-of-flight secondary ion mass spectrometry (ToF–SIMS), has emerged as a powerful tool for biological imag...
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Article
Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases
Metal coordination of bioorganic compounds from both natural and synthetic products is not only gaining recognition in drug design and medicinal inorganic chemistry research, also they are being considered in ...
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Article
A systems biology approach to investigate the antimicrobial activity of oleuropein
Oleuropein and its hydrolysis products are olive phenolic compounds that have antimicrobial effects on a variety of pathogens, with the potential to be utilized in food and pharmaceutical products. While the e...
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Development of a SYBR-based real-time PCR to detect rabbit hemorrhagic disease virus (RHDV) and analyze its tissue distribution in experimentally infected rabbits
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The diversity of nitric oxide function in plant responses to metal stress
Nitric oxide (NO) emerges as signalling molecule, which is involved in diverse physiological processes in plants. High mobility metal interferes with NO signaling. The exogenous NO alleviates metal stress, whe...
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Article
Real-time quantitative analysis of the influence of blue light on citrinin biosynthetic gene cluster expression in Monascus
When Monascus MX was grown under blue light instead of in the dark, citrinin production increased from 478 mg l−1 to 698 mg l−1. To explain this, the expression of the pksCT gene, which encodes citrinin polyketid...
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Article
Mesotoga prima gen. nov., sp. nov., the first described mesophilic species of the Thermotogales
A novel mesophilic member of the Thermotogales, strain MesG1.Ag.4.2, was isolated from sediments from Baltimore Harbor, MD, USA. The strain grew optimally at 37 °C with a doubling time of 16.5 h on xylose. Car...
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Article
Analysis of unculturable bacterial communities in tea orchard soils based on nested PCR-DGGE
The bacterial communities in the soils from tea orchards and their adjacent wasteland in Anhui Province, China were analysed by nested PCR-DGGE technique combined with sequencing. DGGE profiles revealed that t...
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Article
Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex
The organoruthenium complex [(η6-hmb)Ru(en)(Cl)][PF6] (hmb is hexamethylbenzene, en is ethylenediamine) undergoes facile aquation and then reacts with KSCN in unbuffered solution to give the S-coordinated thiocya...