286 Result(s)
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English
Life Sciences
**lin Wu
Article
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Open AccessTaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...
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Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance
Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive (ER+) breast cancer. However, the efficacy of agents such as tamoxifen (Tam) is often ...
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Open AccessCXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that d...
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Spore culture, proliferation and plant regeneration of Platycerium Wallichii Hook via multiple pathways
Platycerium wallichii Hook is a rare and endangered tropical epiphytic fern with ornamental and medicinal value. It is usually propagated by spore germination to produce sporophytes. This study established an in ...
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The function of the ATG8 in the cilia and cortical microtubule maintenance of Euplotes amieti
Autophagy regulates the formation of primary cilia, which in turn affects autophagy. The relationship between autophagy and cilia is known to be bidirectional although the specific mechanisms involved have yet...
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Open AccessExploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation
This study investigates the therapeutic mechanisms of dendrobine, a primary bioactive compound in Dendrobium nobile, for Metabolic Associated Fatty Liver Disease (MASLD) management. Utilizing network pharmacol...
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Open AccessA multilevel investigation to reveal the regulatory mechanism of lignin accumulation in juice sac granulation of pomelo
Granulation of juice sacs is a physiological disorder, which affects pomelo fruit quality. Here, the transcriptome and ubiquitinome of the granulated juice sacs were analyzed in Guanxi pomelo. We found that li...
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Open AccessAntibiotic-induced microbiome depletion promotes intestinal colonization by Campylobacter jejuni in mice
To establish a method to induce Campylobacter jejuni colonization in the intestines of C57BL/6 mice through antibiotic-induced microbiome depletion.
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Open AccessRAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair
RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis (TLS) and homologous recombination (HR) repair. However, whether and how the regulatory mechanism of O-linked N-acetylglu...
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Open AccessTranscriptomic study of the role of MeFtsZ2-1 in pigment accumulation in cassava leaves
MeFtsZ2-1 is a key gene for plant plastid division, but the mechanism by which MeFtsZ2-1 affects pigment accumulation in cassava (Manihot esculenta Crantz) through plastids remains unclear. We found that MeFtsZ2-...
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Open AccessA methodological exploration of distinguishing hair quality based on hair proteomics
Hair is an advantageous biological sample due to its recordable, collectable, and storable nature. Hair's primary components are keratin and keratin-associated proteins. Owing to its abundance of cystine, kera...
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Plant diversity increases spatial stability of aboveground productivity in alpine grasslands
Plant diversity can significantly affect the grassland productivity and its stability. However, it remains unclear how plant diversity affects the spatial stability of natural grassland productivity, especiall...
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Shoot propagation, regeneration, and callus induction and differentiation, of Axonopus compressus (Swartz) Beauv
Axonopus compressus (Swartz) Beauv., a perennial herb in the Poaceae that has been introduced to a number of tropical and subtropical countries and regions, can serve as a lawn ground cover while its leaves can b...
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Open AccessIdentification and characterization of functionally relevant SSR markers in natural Dalbergia odorifera populations
Dalbergia odorifera is a rare and precious rosewood specie, which is valued for its amber tones, abstract figural patterns, and impermeability to water and insects. However, the information on genetic diversity a...
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Ecological rehabilitation of mine tailings
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Complicated target recognition by archaeal box C/D guide RNAs
Box C/D RNAs guide the site-specific formation of 2′-O-methylated nucleotides (Nm) of RNAs in eukaryotes and archaea. Although C/D RNAs have been profiled in several archaea, their targets have not been experimen...
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Open AccessNatural nodulation and nitrogen fixation of Acacia Auriculiformis grown in technosol eco-engineered from Fe ore tailings
Nitrogen deficiency in eco-engineered technosol from iron (Fe) ore tailings limits the productivity of colonising soil microbes and pioneer plants, which are critical to further development of the technosol. S...
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Open AccessCharacterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the ...
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Open AccessMaize multi-omics reveal leaf water status controlling of differential transcriptomes, proteomes and hormones as mechanisms of age-dependent osmotic stress response in leaves
Drought-induced osmotic stress severely affects the growth and yield of maize. However, the mechanisms underlying the different responses of young and old maize leaves to osmotic stress remain unclear. To gain...
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Deoxynivalenol Damages Corneal Epithelial Cells and Exacerbates Inflammatory Response in Fungal Keratitis
Fungal keratitis (FK) is a kind of infectious keratopathy with a high rate of blindness worldwide. Deoxynivalenol (DON) has been proven to have multiple toxic effects on humans and animals.
