131 Result(s)

Article

TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA

Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...

Chong Xu, Jiyanuo Cao, Huanran Qiang, Yu Liu, Jialin Wu, Qiudan Luo… in Genome Biology (2024)

Article

CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity

The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that d...

Chan-Chuan Liu, Wen-Bin Yang, Chia-Hung Chien, Cheng-Lin Wu… in Cell Death & Disease (2024)

Article

Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation

This study investigates the therapeutic mechanisms of dendrobine, a primary bioactive compound in Dendrobium nobile, for Metabolic Associated Fatty Liver Disease (MASLD) management. Utilizing network pharmacol...

Feng Li, Jialin Wu, Ye Zhu, **aoyan Zhang, Miao Wang, Shigao Zhou in Hereditas (2024)

Article

A multilevel investigation to reveal the regulatory mechanism of lignin accumulation in juice sac granulation of pomelo

Granulation of juice sacs is a physiological disorder, which affects pomelo fruit quality. Here, the transcriptome and ubiquitinome of the granulated juice sacs were analyzed in Guanxi pomelo. We found that li...

Luning Liu, Yiran Chen, Weilin Wu, Qiuyou Chen, Zhijiao Tian… in BMC Plant Biology (2024)

Article

Antibiotic-induced microbiome depletion promotes intestinal colonization by Campylobacter jejuni in mice

To establish a method to induce Campylobacter jejuni colonization in the intestines of C57BL/6 mice through antibiotic-induced microbiome depletion.

Haohao Chen, Yanfang Zhang, Yi Pan, Lin Wu, Wenqian Wang, Hui Zhang… in BMC Microbiology (2024)

Article

RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair

RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis (TLS) and homologous recombination (HR) repair. However, whether and how the regulatory mechanism of O-linked N-acetylglu...

**aolu Ma, Hui Fu, Chenyi Sun, Wei Wu, Wenya Hou, Zibin Zhou… in Cell Death & Disease (2024)

Article

Transcriptomic study of the role of MeFtsZ2-1 in pigment accumulation in cassava leaves

MeFtsZ2-1 is a key gene for plant plastid division, but the mechanism by which MeFtsZ2-1 affects pigment accumulation in cassava (Manihot esculenta Crantz) through plastids remains unclear. We found that MeFtsZ2-...

Yuwei Zang, Kunlin Wu, Liangwang Liu, Fangfang Ran, Changyi Wang, Shuwen Wu… in BMC Genomics (2024)

Article

A methodological exploration of distinguishing hair quality based on hair proteomics

Hair is an advantageous biological sample due to its recordable, collectable, and storable nature. Hair's primary components are keratin and keratin-associated proteins. Owing to its abundance of cystine, kera...

**aolin Wu, Tao Zhang, Mingsong Mao, Yali Zhang, Zhenpeng Zhang… in Proteome Science (2024)

Article

Identification and characterization of functionally relevant SSR markers in natural Dalbergia odorifera populations

Dalbergia odorifera is a rare and precious rosewood specie, which is valued for its amber tones, abstract figural patterns, and impermeability to water and insects. However, the information on genetic diversity a...

Jieru Xu, Yue Wang, Kunlin Wu, **hui Chen in BMC Plant Biology (2024)

Article

Ecological rehabilitation of mine tailings

Songlin Wu, Fayuan Wang, Michael Komárek, Longbin Huang in Plant and Soil (2024)

Article

Natural nodulation and nitrogen fixation of Acacia Auriculiformis grown in technosol eco-engineered from Fe ore tailings

Nitrogen deficiency in eco-engineered technosol from iron (Fe) ore tailings limits the productivity of colonising soil microbes and pioneer plants, which are critical to further development of the technosol. S...

Zhen Li, Songlin Wu, Yunjia Liu, Fang You, Merinda Hall, Longbin Huang in Plant and Soil (2024)

Article

Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the ...

Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia… in Communications Biology (2024)

Article

Maize multi-omics reveal leaf water status controlling of differential transcriptomes, proteomes and hormones as mechanisms of age-dependent osmotic stress response in leaves

Drought-induced osmotic stress severely affects the growth and yield of maize. However, the mechanisms underlying the different responses of young and old maize leaves to osmotic stress remain unclear. To gain...

Liangjie Niu, Wenkang Wang, Yingxue Li, **aolin Wu, Wei Wang in Stress Biology (2024)

Article

KCTD15 acts as an anti-tumor factor in colorectal cancer cells downstream of the demethylase FTO and the m6A reader YTHDF2

Potassium Channel Tetramerization Domain Containing 15 (KCTD15) participates in the carcinogenesis of several solid malignancies; however, its role in colorectal cancer (CRC) remains unclear. Here we find that...

Fang-Yuan Zhang, Lin Wu, Tie-Ning Zhang, Huan-Huan Chen in Communications Biology (2024)

Article

Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection

Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast cancer and cardiovascular disease. Exosomes derive...

Fangfang Dai, Hua Liu, Juan He, **glin Wu, Chaoyan Yuan… in Stem Cell Research & Therapy (2024)

Article

Correction: The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment

Bisheng Cheng, Lingfeng Li, Yongxin Wu, Tianlong Luo, Chen Tang… in Cell & Bioscience (2024)

Article

Evaluation of a novel lysis-based sample processing method to optimize Vibrio vulnificus detecting by loop-mediated isothermal amplification assay

Vibrio vulnificus exists as one of the most serious foodborne pathogens for humans, and rapid and sensitive detection methods are needed to control its infections. As an emerging method, The Loop-Mediated Isother...

Lei Zhang, Jianfei Liu, Kewei Qin, Chenglin Wu, Hui Ma, Lijun Zhou in BMC Microbiology (2024)

Article

Epigenetic addition of m⁵C to HBV transcripts promotes viral replication and evasion of innate antiviral responses

Eukaryotic five-methylcytosine (m⁵C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m⁵C sites ...

Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu… in Cell Death & Disease (2024)

Article

Characterizing immune variation and diagnostic indicators of preeclampsia by single-cell RNA sequencing and machine learning

Preeclampsia is a multifactorial and heterogeneous complication of pregnancy. Here, we utilize single-cell RNA sequencing to dissect the involvement of circulating immune cells in preeclampsia. Our findings re...

Wenwen Zhou, Yixuan Chen, Yuhui Zheng, Yong Bai, Jianhua Yin… in Communications Biology (2024)

Article

Comparative chloroplast genomics of 24 species shed light on the genome evolution and phylogeny of subtribe Coelogyninae (Orchidaceae)

The orchids of the subtribe Coelogyninae are among the most morphologically diverse and economically important groups within the subfamily Epidendroideae. Previous molecular studies have revealed that Coelogyn...

Lin Li, Qiu** Wu, Junwen Zhai, Kunlin Wu, Lin Fang, Mingzhi Li… in BMC Plant Biology (2024)