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Open AccessSingle-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
Docetaxel resistance represents a significant obstacle in the treatment of prostate cancer. The intricate interplay between cytokine signalling pathways and transcriptional control mechanisms in cancer cells c...
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Open AccessCorrection: The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
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Article
Open AccessA protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3
Circular RNAs (circRNAs) are a family of endogenous RNAs that have become a focus of biological research in recent years. Emerging evidence has revealed that circRNAs exert biological functions by acting as tr...
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Article
Open AccessThe key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
Prostate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in patients with castration-resistant prostate cancer ...
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Article
Open AccessARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression
Chronic inflammation and an immunosuppressive microenvironment promote prostate cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) therapies. However, it remains unclear how...
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Article
Bladder cancer biomarker screening based on non-targeted urine metabolomics
Bladder cancer is one of the most common malignancies of the urinary system, and its screening relies heavily on invasive cystoscopy, which increases the risk of urethral injury and infection. This study aims ...
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Article
Open AccessThe efficacy of cytoreductive surgery for oligometastatic prostate cancer: a meta-analysis
At present, the application of tumor reduction surgery in oligometastatic prostate cancer has aroused extensive discussion among urologists, but clinicians have not reached a consensus on this issue. The purpo...
