76 Result(s)

Article

Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma

G-protein-coupled receptor 120 (GPR120) functions as a receptor for unsaturated long-chain free fatty acids and has an important role in regulating lipid and glucose metabolism. However, a role for GPR120 in t...

Q Wu, H Wang, X Zhao, Y Shi, M **, B Wan, H Xu, Y Cheng, H Ge, Y Zhang in Oncogene (2013)

Article

Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells

Although the intensification of therapy for children with T-cell acute lymphoblastic leukemia (T-ALL) has substantially improved clinical outcomes, T-ALL remains an important challenge in pediatric oncology. H...

C Lu, J-Y Li, Z Ge, L Zhang, G-P Zhou in Oncogene (2013)

Article

Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation

Human DCTPP1 (dCTP pyrophosphatase 1), also known as XTP3-transactivated protein A, belongs to MazG-like nucleoside triphosphate pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatas...

F-f Song, L-l **a, P Ji, Y-b Tang, Z-m Huang, L Zhu, J Zhang, J-q Wang… in Oncogenesis (2015)

Article

Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways

Although death receptor 6 (DR6) is aberrantly expressed in certain cancer cell lines, its function, signaling pathway and potential clinical significance in tumor progression are not well characterized. We rep...

X Yang, B Shi, L Li, Z Xu, Y Ge, J Shi, Y Liu, D Zheng in Oncogenesis (2016)

Article

Egr-1 regulates irradiation-induced autophagy through Atg4B to promote radioresistance in hepatocellular carcinoma cells

Although hepatocellular carcinoma (HCC) is usually response to radiation therapy, radioresistance is still the major obstacle that limits the efficacy of radiotherapy for HCC patients. Therefore, further inves...

W-x Peng, Y-y Wan, A-h Gong, L Ge, J **, M Xu, C-y Wu in Oncogenesis (2017)

Article

Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy (usually cytarabine) often deve...

Daniel A Luedtke, **aojia Niu, Yihang Pan… in Signal Transduction and Targeted Therapy (2017)

Article

Downregulation of miR-218 contributes to epithelial–mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling

Epithelial–mesenchymal transition (EMT) has been recognized as a key element of cell migration and invasion in lung cancer; however, the underlying mechanisms are not fully elucidated. Recently, emerging evide...

Z-M Shi, L Wang, H Shen, C-F Jiang, X Ge, D-M Li, Y-Y Wen, H-R Sun, M-H Pan… in Oncogene (2017)

Article

circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family

Circular RNAs (circRNAs) represent a class of non-coding RNAs that are widely expressed in mammals. However, it is largely unknown about the function of human circRNAs and the roles of circRNAs in human oral s...

L Chen, S Zhang, J Wu, J Cui, L Zhong, L Zeng, S Ge in Oncogene (2017)

Article

Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated th...

Hua Guo, Yangyang Ge, **ao** Li, Yanlian Yang… in Signal Transduction and Targeted Therapy (2017)

Article

Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1

Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that promote cancer cell invasive growth and metastasis, yet the mechanisms mediating these functions still largely remain elusive. We...

Noriaki Tanaka, Mei Zhao, Lin Tang, Ameeta A. Patel, Qing **, Hieu T. Van… in Oncogene (2018)

Article

Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis

It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth factor A (VEGFA) axis to promote angiogenesis in breast cancer. However, it is unclear how ...

Huichun Liang, Ji **ao, Zhongmei Zhou, Jiao Wu, Fei Ge, Zongcheng Li… in Oncogene (2018)

Article

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia

Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing protein 5B (ARID5B) are involved in the oncogenesis of acute lymphoblastic leukemia (ALL) and treatment outcomes. However,...

Zheng Ge, Qi Han, Yan Gu, Qinyu Ge, **long Ma, Justin Sloane, Guofeng Gao… in Oncogenesis (2018)

Article

PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma

Lung cancer is the leading cause of cancer-related mortality worldwide. PEST-containing nuclear protein (PCNP) has been found in the nucleus of cancer cells. Whether PCNP plays a role in the growth of lung ade...

Da-Yong Wang, Ya Hong, Ya-Ge Chen, Peng-Zhen Dong, Shi-Yu Liu, Ying-Ran Gao… in Oncogenesis (2019)

Article

RETRACTED ARTICLE: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage and metabolism regulation by the secreti...

Haiyang Zhang, Ting Deng, Shaohua Ge, Ying Liu, Ming Bai, Kegan Zhu, Qian Fan… in Oncogene (2019)

Article

Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis

Long noncoding RNAs (lncRNAs) play an important role in lung adenocarcinoma (LUAD) metastasis. Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients wit...

**aolu Ge, Gui-yuan Li, Lin Jiang, Liqing Jia, Zhezhe Zhang, **aoling Li… in Oncogene (2019)

Article

Retraction Note: circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family

The Editors and Publisher have agreed to retract the above paper following a request from the authors.

L. Chen, S. Zhang, J. Wu, J. Cui, L. Zhong, L. Zeng, S. Ge in Oncogene (2019)

Article

Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Tingting Wang, Margaret Shatara, Fangbing Liu… in Signal Transduction and Targeted Therapy (2019)

Article

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

Venetoclax, an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (AML), is tolerated well in elderly patients with AML and has good overall res...

Daniel A. Luedtke, Yongwei Su, Jun Ma, **nyu Li… in Signal Transduction and Targeted Therapy (2020)

Article

Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin

Enhanced migration is pivotal for the malignant development of glioblastoma (GBM), but the underlying molecular mechanism that modulates the migration of the GBM cells remains obscure. Here we show that nuclea...

Zhuohao Liu, Ruixiang Ge, Jiayi Zhou, **nzhi Yang, Kenneth King-yip Cheng… in Oncogenesis (2020)

Article

SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

Sirtuin 7 (SIRT7), an NAD⁺-dependent deacetylase, plays vital roles in energy sensing, but the underlying mechanisms of action remain less clear. Here, we report that SIRT7 is required for p53-dependent cell-cycl...

Ya-Fei Lu, **ao-Peng Xu, **ao-Peng Lu, Qian Zhu, Ge Liu, Yan-Tao Bao, He Wen… in Oncogene (2020)