82 Result(s)

Article

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia

C Song, X Pan, Z Ge, C Gowda, Y Ding, H Li, Z Li, G Yochum, M Muschen, Q Li… in Leukemia (2016)

Article

Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy (usually cytarabine) often deve...

Daniel A Luedtke, **aojia Niu, Yihang Pan… in Signal Transduction and Targeted Therapy (2017)

Article

Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated th...

Hua Guo, Yangyang Ge, **ao** Li, Yanlian Yang… in Signal Transduction and Targeted Therapy (2017)

Article

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study

In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lo...

Reinhard Stauder, Ge Yu, Karin A. Koinig, Tim Bagguley, Pierre Fenaux… in Leukemia (2018)

Article

Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Tingting Wang, Margaret Shatara, Fangbing Liu… in Signal Transduction and Targeted Therapy (2019)

Article

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ikaros encodes a transcription factor that functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). The mechanisms through which Ikaros regulates gene expression and cellular proliferation ...

Yali Ding, Bo Zhang, Jonathon L. Payne, Chunhua Song, Zheng Ge, Chandrika Gowda… in Leukemia (2019)

Article

Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia

Shifen Wang, Maolin Ge, **g Cui, Zhi Qiao, **uli Chen, Shunquan Wu, Rong Zhan… in Leukemia (2019)

Article

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

Venetoclax, an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (AML), is tolerated well in elderly patients with AML and has good overall res...

Daniel A. Luedtke, Yongwei Su, Jun Ma, **nyu Li… in Signal Transduction and Targeted Therapy (2020)

Article

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein

Geng Chen, **ankun Wang, Yunjun Ge, Ling Ma… in Signal Transduction and Targeted Therapy (2020)

Article

Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia

Shouhai Zhu, **aoyan Cheng, Ruiheng Wang, Yuting Tan, Maolin Ge, Dan Li… in Leukemia (2020)

Article

Microbiome dysbiosis in lung cancer: from composition to therapy

The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The...

Ning-Ning Liu, Qiang Ma, Yang Ge, Cheng-**ang Yi, Lu-Qi Wei… in npj Precision Oncology (2020)

Article

Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common form of acute leukemia in children. Despite this, very little improvement in survival rates has been ...

Jenna L. Carter, Katie Hege, Jay Yang… in Signal Transduction and Targeted Therapy (2020)

Article

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...

**ao-Yue Hong, Hua-Li Wan, Ting Li… in Signal Transduction and Targeted Therapy (2020)

Article

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...

Xuekun Fu, Bo Zhou, Qinnan Yan, Chu Tao… in Signal Transduction and Targeted Therapy (2020)

Article

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male ...

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma… in Signal Transduction and Targeted Therapy (2021)

Article

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19). In this study,...

Yiyue Ge, Tingzhong Tian, Suling Huang… in Signal Transduction and Targeted Therapy (2021)

Article

Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia

Children of Hispanic/Latino ancestry have increased incidence of high-risk B-cell acute lymphoblastic leukemia (HR B-ALL) with poor prognosis. This leukemia is characterized by a single-copy deletion of the IKZF1

Zheng Ge, Chunhua Song, Yali Ding, Bi-Hua Tan, Dhimant Desai, Arati Sharma… in Leukemia (2021)

Article

Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19

COVID-19 remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity. Here, we present the oropharyngeal micro...

Shengli Ma, Fan Zhang, Fengxia Zhou, Hui Li… in Signal Transduction and Targeted Therapy (2021)

Article

CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4

Ka** Lee, Qiufan Zheng, Qianyi Lu, Fei Xu… in Signal Transduction and Targeted Therapy (2021)

Article

The arsenal of TP53 mutants therapies: neoantigens and bispecific antibodies

Chang Yang, Ge Lou, Wei-Lin ** in Signal Transduction and Targeted Therapy (2021)