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  1. Article

    Open Access

    Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

    TREM2 is a microglial receptor genetically linked to the risk for Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease p...

    Xuan Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu in Journal of Neuroinflammation (2021)

  2. No Access

    Article

    Contribution of Baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats

    Neuropeptide Y (NPY), a metabolism-related cardiovascular factor, plays a crucial role in blood pressure (BP) regulation via peripheral and central pathways. The expression of NPY receptors (Y1R/Y2R) specific to ...

    Yang Liu, Shu-Yang Zhao, Yan Feng, Jie Sun, **ao-Long Lu in Neuroscience Bulletin (2020)

  3. Article

    Open Access

    Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

    TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. Whi...

    Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens in Molecular Neurodegeneration (2018)

  4. No Access

    Article

    Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation

    The aim of this study is to investigate the role and mechanism of microglial NOX2 activation in minimally toxic dose of LPS and Syn-elicited synergistic dopaminergic neurodegeneration. NOX2+/+ and NOX2−/− mice an...

    Wei Zhang, Jun-hua Gao, Zhao-fen Yan, **-yan Huang, Peng Guo in Molecular Neurobiology (2018)

  5. Article

    Open Access

    LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

    Neuroinflammation is characterized by microglial activation and the increased levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence has implicated both beneficial and toxic ro...

    Longyu Yang, Chia-Chen Liu, Honghua Zheng in Journal of Neuroinflammation (2016)

  6. Article

    Open Access

    A rapid and cost-effective method for genoty** apolipoprotein E gene polymorphism

    Apolipoprotein E (ApoE) is a major cholesterol carrier and plays an important role in maintaining lipid homeostasis both in the periphery and brain. Human APOE gene is polymorphic at two single nucleotides (rs429...

    Li Zhong, Yong-Zhuang **e, Tian-Tian Cao, Zongqi Wang in Molecular Neurodegeneration (2016)

  7. No Access

    Article

    Role and Mechanism of Microglial Activation in Iron-Induced Selective and Progressive Dopaminergic Neurodegeneration

    Parkinson’s disease (PD) patients have excessive iron depositions in substantia nigra (SN). Neuroinflammation characterized by microglial activation is pivotal for dopaminergic neurodegeneration in PD. However...

    Wei Zhang, Zhao-fen Yan, Jun-hua Gao, Li Sun, **-yan Huang in Molecular Neurobiology (2014)

  8. Article

    Open Access

    Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats

    Intracerebral hemorrhage (ICH) remains a serious clinical problem lacking effective treatment. Urocortin (UCN), a novel anti-inflammatory neuropeptide, protects injured cardiomyocytes and dopaminergic neurons....

    Hock-Kean Liew, Cheng-Yoong Pang, Chih-Wei Hsu in Journal of Neuroinflammation (2012)