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Open AccessCREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms
Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genom...
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Article
Open AccessIdentification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy
Oculomotor nerve palsy (ONP) is a neuroparalytic disorder resulting in dysfunction of innervating extraocular muscles (EOMs), of which the pathological characteristics remain underexplored.
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Article
Open AccessGenome-wide analysis of the MADS-box gene family in Lonicera japonica and a proposed floral organ identity model
Lonicera japonica Thunb. is widely used in traditional Chinese medicine. Medicinal L. japonica mainly consists of dried flower buds and partially opened flowers, thus flowers are an important quality indicator. M...
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Article
Open AccessLineage-specific amplification and epigenetic regulation of LTR-retrotransposons contribute to the structure, evolution, and function of Fabaceae species
Long terminal repeat (LTR)-retrotransposons (LTR-RTs) are ubiquitous and make up the majority of nearly all sequenced plant genomes, whereas their pivotal roles in genome evolution, gene expression regulation ...
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RETRACTED ARTICLE: Renal enhanced CT images reveal the tandem mechanism between tumor cells and immunocytes based on bulk/single-cell RNA sequencing
Metabolic reprogramming is essential for establishing the tumor microenvironment (TME). Glutamine has been implicated in cancer metabolism, but its role in clear cell renal carcinoma (ccRCC) remains unknown. T...
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Article
Open AccessCRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in develo** zebrafish embryos
Understanding gene transcription and mRNA-protein (mRNP) dynamics in single cells in a multicellular organism has been challenging. The catalytically dead CRISPR-Cas13 (dCas13) system has been used to visualiz...
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Article
Open AccessTranscriptome analysis of critical genes related to flowering in Mikania micrantha at different altitudes provides insights for a potential control
Mikania micrantha is a vine with strong invasion ability, and its strong sexual reproduction ability is not only the main factor of harm, but also a serious obstacle to control. M. micrantha spreads mainly throug...
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Article
Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Article
Open AccessComparative analysis of mitochondrial genomes reveals marine adaptation in seagrasses
Seagrasses are higher marine flowering plants that evolved from terrestrial plants, but returned to the sea during the early evolution of monocotyledons through several separate lineages. Thus, they become a g...
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Article
Open AccessProteomics data analysis using multiple statistical approaches identified proteins and metabolic networks associated with sucrose accumulation in sugarcane
Sugarcane is the most important sugar crop, contributing > 80% of global sugar production. High sucrose content is a key target of sugarcane breeding, yet sucrose improvement in sugarcane remains extremely slo...
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Article
Open AccessGenome-wide investigation and expression profiling of polyphenol oxidase (PPO) family genes uncover likely functions in organ development and stress responses in Populus trichocarpa
Trees such as Populus are planted extensively for reforestation and afforestation. However, their successful establishment greatly depends upon ambient environmental conditions and their relative resistance to ab...
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Article
Open AccessGenetic dissection of eating and cooking qualities in different subpopulations of cultivated rice (Oryza sativa L.) through association map**
Eating and cooking qualities (ECQs) of rice (Oryza sativa L.) determine consumer acceptance and the economic value of rice varieties. The starch physicochemical properties, i.e. amylose content, gel consistency, ...
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Article
The jasmonate-responsive transcription factor CbWRKY24 regulates terpenoid biosynthetic genes to promote saponin biosynthesis in Conyza blinii H. Lév.
Conyza blinii H. Lév., the most effective component is saponin, is a biennial medicinal material that needs to be overwintered. WRKY transcription factors family is a large protein superfamily that plays a predom...
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Article
Soybean (Glycine max) WRINKLED1 transcription factor, GmWRI1a, positively regulates seed oil accumulation
Soybean is the world’s most important leguminous crop producing high-quality protein and oil. Elevating oil accumulation in soybean seed is always many researchers’ goal. WRINKLED1 (WRI1) encodes a transcripti...
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Open AccessIdentification of putative markers linked to grain plumpness in rice (Oryza sativa L.) via association map**
Poor grain plumpness (GP) is one of the main constraints to reaching the yield potential of hybrid rice.
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Open AccessBayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells
Single-molecule RNA fluorescence in situ hybridization (smFISH) provides unparalleled resolution in the measurement of the abundance and localization of nascent and mature RNA transcripts in fixed, single cell...
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Article
Molecular identification of differential expression genes associated with sex pheromone biosynthesis in Spodoptera exigua
Species-specific sex pheromone is biosynthesized and released in most female moths as a chemical cue in mating communication. However, information on genes involved in this pathway is limited. The beet armyworm,
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Article
Open AccessPlant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identi...
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Article
Open AccessTranscriptome profiling reveals the genetic basis of alkalinity tolerance in wheat
Soil alkalinity shows significant constraints to crop productivity; however, much less attention has been paid to analyze the effect of soil alkalinity on plant growth and development. Shanrong No. 4 (SR4) is ...
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Open AccessTranscriptome analysis of the effect of Vibrio alginolyticus infection on the innate immunity-related complement pathway in Epinephelus coioides
Orange-spotted grouper (Epinephelus coioides) with protogynous hermaphroditic features are one of the most economically important aquaculture species in Taiwan. However, larvae stage grouper are susceptible to in...