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  1. Article

    Open Access

    CREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms

    Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genom...

    Yongge Li, Fusong Ju, Zhiyuan Chen, Yiming Qu, Huanhuan **a, Liang He in Genome Biology (2023)

  2. Article

    Open Access

    Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy

    Oculomotor nerve palsy (ONP) is a neuroparalytic disorder resulting in dysfunction of innervating extraocular muscles (EOMs), of which the pathological characteristics remain underexplored.

    Mingsu Shi, Yanxi Fang, Yu Liang, Yuxiang Hu, Jiaqiu Huang, Weiyi **a in BMC Genomics (2023)

  3. Article

    Open Access

    Genome-wide analysis of the MADS-box gene family in Lonicera japonica and a proposed floral organ identity model

    Lonicera japonica Thunb. is widely used in traditional Chinese medicine. Medicinal L. japonica mainly consists of dried flower buds and partially opened flowers, thus flowers are an important quality indicator. M...

    Yi Lin, **wu Qi, Yan Wan, Zequn Chen, Hailing Fang, Chengyuan Liang in BMC Genomics (2023)

  4. Article

    Open Access

    Lineage-specific amplification and epigenetic regulation of LTR-retrotransposons contribute to the structure, evolution, and function of Fabaceae species

    Long terminal repeat (LTR)-retrotransposons (LTR-RTs) are ubiquitous and make up the majority of nearly all sequenced plant genomes, whereas their pivotal roles in genome evolution, gene expression regulation ...

    Long-Long Yang, **n-Yu Zhang, Li-Ying Wang, Yan-Ge Li, **ao-Ting Li in BMC Genomics (2023)

  5. No Access

    Article

    RETRACTED ARTICLE: Renal enhanced CT images reveal the tandem mechanism between tumor cells and immunocytes based on bulk/single-cell RNA sequencing

    Metabolic reprogramming is essential for establishing the tumor microenvironment (TME). Glutamine has been implicated in cancer metabolism, but its role in clear cell renal carcinoma (ccRCC) remains unknown. T...

    Haote Liang, Keming Wu, Rongrong Wu, KaTe Huang in Functional & Integrative Genomics (2023)

  6. Article

    Open Access

    CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in develo** zebrafish embryos

    Understanding gene transcription and mRNA-protein (mRNP) dynamics in single cells in a multicellular organism has been challenging. The catalytically dead CRISPR-Cas13 (dCas13) system has been used to visualiz...

    Youkui Huang, Bao-Qing Gao, Quan Meng, Liang-Zhong Yang, Xu-Kai Ma in Genome Biology (2023)

  7. Article

    Open Access

    Transcriptome analysis of critical genes related to flowering in Mikania micrantha at different altitudes provides insights for a potential control

    Mikania micrantha is a vine with strong invasion ability, and its strong sexual reproduction ability is not only the main factor of harm, but also a serious obstacle to control. M. micrantha spreads mainly throug...

    Chen Liang, Ling Liu, Zhixiao Zhang, Sangzi Ze, Ling Pei, Lichen Feng in BMC Genomics (2023)

  8. Article

    Open Access

    Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...

    Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka in Genome Biology (2022)

  9. Article

    Open Access

    Comparative analysis of mitochondrial genomes reveals marine adaptation in seagrasses

    Seagrasses are higher marine flowering plants that evolved from terrestrial plants, but returned to the sea during the early evolution of monocotyledons through several separate lineages. Thus, they become a g...

    Jun Chen, Yu Zang, Shuo Liang, Song Xue, Shuai Shang, Meiling Zhu in BMC Genomics (2022)

  10. Article

    Open Access

    Proteomics data analysis using multiple statistical approaches identified proteins and metabolic networks associated with sucrose accumulation in sugarcane

    Sugarcane is the most important sugar crop, contributing > 80% of global sugar production. High sucrose content is a key target of sugarcane breeding, yet sucrose improvement in sugarcane remains extremely slo...

    Ao-Mei Li, Zhong-Liang Chen, Cui-**an Qin, Zi-Tong Li, Fen Liao in BMC Genomics (2022)

  11. Article

    Open Access

    Genome-wide investigation and expression profiling of polyphenol oxidase (PPO) family genes uncover likely functions in organ development and stress responses in Populus trichocarpa

    Trees such as Populus are planted extensively for reforestation and afforestation. However, their successful establishment greatly depends upon ambient environmental conditions and their relative resistance to ab...

    Fang He, Yu-Jie Shi, Qian Zhao, Kuang-Ji Zhao, **ng-Lei Cui, Liang-Hua Chen in BMC Genomics (2021)

  12. Article

    Open Access

    Genetic dissection of eating and cooking qualities in different subpopulations of cultivated rice (Oryza sativa L.) through association map**

    Eating and cooking qualities (ECQs) of rice (Oryza sativa L.) determine consumer acceptance and the economic value of rice varieties. The starch physicochemical properties, i.e. amylose content, gel consistency, ...

    Chunfang Zhao, Ling Zhao, Qingyong Zhao, Tao Chen, Shu Yao, Zhen Zhu in BMC Genetics (2020)

  13. No Access

    Article

    The jasmonate-responsive transcription factor CbWRKY24 regulates terpenoid biosynthetic genes to promote saponin biosynthesis in Conyza blinii H. Lév.

    Conyza blinii H. Lév., the most effective component is saponin, is a biennial medicinal material that needs to be overwintered. WRKY transcription factors family is a large protein superfamily that plays a predom...

    Wen-Jun Sun, Jun-Yi Zhan, Tian-Run Zheng, Rong Sun, Tao Wang in Journal of Genetics (2018)

  14. No Access

    Article

    Soybean (Glycine max) WRINKLED1 transcription factor, GmWRI1a, positively regulates seed oil accumulation

    Soybean is the world’s most important leguminous crop producing high-quality protein and oil. Elevating oil accumulation in soybean seed is always many researchers’ goal. WRINKLED1 (WRI1) encodes a transcripti...

    Liang Chen, Yuhong Zheng, Zhimin Dong, Fanfan Meng in Molecular Genetics and Genomics (2018)

  15. Article

    Open Access

    Identification of putative markers linked to grain plumpness in rice (Oryza sativa L.) via association map**

    Poor grain plumpness (GP) is one of the main constraints to reaching the yield potential of hybrid rice.

    Erbao Liu, Siyuan Zeng, **angong Chen, **ao**g Dang, Lijun Liang, Hui Wang in BMC Genetics (2017)

  16. Article

    Open Access

    BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells

    Single-molecule RNA fluorescence in situ hybridization (smFISH) provides unparalleled resolution in the measurement of the abundance and localization of nascent and mature RNA transcripts in fixed, single cell...

    Mariana Gómez-Schiavon, Liang-Fu Chen, Anne E. West, Nicolas E. Buchler in Genome Biology (2017)

  17. No Access

    Article

    Molecular identification of differential expression genes associated with sex pheromone biosynthesis in Spodoptera exigua

    Species-specific sex pheromone is biosynthesized and released in most female moths as a chemical cue in mating communication. However, information on genes involved in this pathway is limited. The beet armyworm,

    Ya-Nan Zhang, Long-Wa Zhang, Da-Song Chen, Liang Sun in Molecular Genetics and Genomics (2017)

  18. Article

    Open Access

    Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi

    Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identi...

    Yu-Chen Liu, Wen Liang Chen, Wei-Hsiang Kung, Hsien-Da Huang in BMC Genomics (2017)

  19. Article

    Open Access

    Transcriptome profiling reveals the genetic basis of alkalinity tolerance in wheat

    Soil alkalinity shows significant constraints to crop productivity; however, much less attention has been paid to analyze the effect of soil alkalinity on plant growth and development. Shanrong No. 4 (SR4) is ...

    Chen Meng, Tai-Yong Quan, Zhong-Yi Li, Kang-Li Cui, Li Yan, Yu Liang in BMC Genomics (2017)

  20. Article

    Open Access

    Transcriptome analysis of the effect of Vibrio alginolyticus infection on the innate immunity-related complement pathway in Epinephelus coioides

    Orange-spotted grouper (Epinephelus coioides) with protogynous hermaphroditic features are one of the most economically important aquaculture species in Taiwan. However, larvae stage grouper are susceptible to in...

    Yi-Da Wang, Shin-Jie Huang, Hong-Nong Chou, Wen-Liang Liao, Hong-Yi Gong in BMC Genomics (2014)

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