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  1. No Access

    Article

    Dysregulation of Circulatory Levels of lncRNAs in Parkinson’s Disease

    Emerging evidence suggested that long non-coding RNAs (lncRNAs) were involved in Parkinson’s disease (PD) pathogenesis. Herein, we used gene expression profiles from GEO database to construct a PD-specific ceR...

    Ting Huang, **-Ying Zhao, Rong-Rong Pan, Teng Jiang, **n-**n Fu… in Molecular Neurobiology (2023)

  2. No Access

    Article

    Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice

    Recent pre-clinical and clinical studies suggest that general anesthesia in infants and children may increase the risk of learning disabilities. Currently, there is no treatment for preventing anesthesia-induc...

    Chun-Ling Dai, Hengchang Li, **n Hu, ** Zhang, Fei Liu… in Neurotoxicity Research (2020)

  3. No Access

    Article

    Pathological Alterations of Tau in Alzheimer’s Disease and 3xTg-AD Mouse Brains

    Microtubule-associated protein tau in Alzheimer’s disease (AD) brain is hyperphosphorylated, truncated, and aggregated into neurofibrillary tangles. Oligomeric and hyperphosphorylated tau (Oligo-tau) isolated ...

    Longfei Li, Yanli Jiang, Wen Hu, Yunn Chyn Tung, Chunling Dai… in Molecular Neurobiology (2019)

  4. Article

    Open Access

    Overexpression of SNHG12 regulates the viability and invasion of renal cell carcinoma cells through modulation of HIF1α

    Cumulative evidences demonstrated the aberrant overexpression of Small Nucleolar RNA Host Gene 12 (SNHG12) in diverse human cancer. However, the expression status and involvement of SNHG12 in renal cell carcin...

    Qiguang Chen, Wei Zhou, Shu-qi Du, Da-xin Gong, Jun Li… in Cancer Cell International (2019)

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  5. No Access

    Article

    Activation of VEGF/Flk-1-ERK Pathway Induced Blood–Brain Barrier Injury After Microwave Exposure

    Microwaves have been suggested to induce neuronal injury and increase permeability of the blood–brain barrier (BBB), but the mechanism remains unknown. The role of the vascular endothelial growth factor (VEGF)...

    Li-Feng Wang, **ang Li, Ya-Bing Gao, Shui-Ming Wang, Li Zhao… in Molecular Neurobiology (2015)

  6. No Access

    Article

    Nicotine Inhibits Microglial Proliferation and Is Neuroprotective in Global Ischemia Rats

    Ischemic injury in rodent models reliably leads to the activation of microglia, which might play a detrimental role in neuronal survival. Our preliminary studies suggest that nicotine plays a potential role in...

    Yan-Zhong Guan, **u-Dong **, Li-**n Guan, Hua-Cheng Yan, Pu Wang… in Molecular Neurobiology (2015)

  7. No Access

    Article

    From Chronic Cerebral Hypoperfusion to Alzheimer-Like Brain Pathology and Neurodegeneration

    Chronic cerebral hypoperfusion (CCH) is a common consequence of various cerebral vascular disorders and hemodynamic and blood changes. Recent studies have revealed an important role of CCH in neurodegeneration...

    Yang Zhao, Cheng-**n Gong in Cellular and Molecular Neurobiology (2015)

  8. No Access

    Article

    Cyclic AMP-Dependent Protein Kinase Enhances SC35-Promoted Tau Exon 10 Inclusion

    Alternative splicing of tau exon 10 generates tau with three or four microtubule-binding repeats (3R-tau or 4R-tau). The ratio of 3R-tau to 4R-tau is approximately 1:1 in the adult normal human brain. Disturba...

    Caoyi Chen, Nana **, Wei Qian, Wen Liu, **angling Tan, Fei Ding… in Molecular Neurobiology (2014)

  9. No Access

    Article

    Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice

    Alzheimer's disease (AD) involves several possible molecular mechanisms, including impaired brain insulin signaling and glucose metabolism. To investigate the role of metabolic insults in AD, we injected strep...

    Yanxing Chen, Zhihou Liang, Zhu Tian, Julie Blanchard… in Molecular Neurobiology (2014)

  10. No Access

    Article

    A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

    Alzheimer’s disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD). Most AD cases are sporadic and result from multiple etiologic factors, including environmental, genetic, and metabolic fact...

    Yanxing Chen, Zhihou Liang, Julie Blanchard, Chun-Ling Dai… in Molecular Neurobiology (2013)

  11. No Access

    Article

    Alzheimer neurofibrillary degeneration

    Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this lesion offers a promising therapeutic approach. The ...

    Khalid Iqbal, Alejandra del C. Alonso, Ezzat El-Akkad… in Journal of Molecular Neuroscience (2003)

  12. No Access

    Article

    Significance and mechanism of alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

    Abnormally hyperphosphorylated tau which is the major protein subunit of paired helical filaments (PHF)/neurofibrillary tangles is the pivotal lesion in Alzheimer disease (AD) and related tauopathies. The cose...

    Khalid Iqbal, Alejandra del C. Alonso, Ezzat El-Akkad… in Journal of Molecular Neuroscience (2002)

  13. No Access

    Article

    Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Nonbinding Phosphatase Activities

    Phosphatases extracted from a human brain were resolved into two main groups, namely affi-gel blue-binding phosphatases and affi-gel blue-nonbinding phosphatases. Affi-gel blue binding phosphatases were furthe...

    Li Yao Cheng, Jian-Zhi Wang, Cheng-**n Gong, **-**g Pei… in Neurochemical Research (2001)

  14. No Access

    Article

    Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Binding Phosphatases

    Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel w...

    Li Yao Cheng, Jian-Zhi Wang, Cheng-**n Gong, **-**g Pei… in Neurochemical Research (2000)

  15. No Access

    Article

    Mechanism of neurofibrillary degeneration in Alzheimer's disease

    Neurofibrillary degeneration associated with the formation of intraneuronal neurofibrillary tangles of paired helical filaments (PHF) and 2.1 nm τ filaments is one of the most characteristic brain lesions of A...

    Khalid Iqbal, Alejandra del C. Alonso, Cheng-**n Gong… in Molecular Neurobiology (1994)