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Article
Open AccessCerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients
Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the asso...
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Article
Open AccessThe relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants
Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common pathogenesis for dementia. We hypothesize...
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Article
Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China
Essential tremor (ET) is a neurological disease characterized by action tremor in upper arms. Although its high heritability and prevalence worldwide, its etiology and association with other diseases are still...
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Article
PFKFB2 is a favorable prognostic biomarker for colorectal cancer by suppressing metastasis and tumor glycolysis
This study was to investigate the biological effect of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) in colorectal cancer (CRC).
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Article
Salivary Aβ1–42 may be a quick-tested biomarker for clinical use in Alzheimer’s disease: a meta-analysis
Alzheimer’s disease (AD) is the most prevalent form of dementia among the aging population. Cumulative studies aim to find non-invasive biomarkers in the early stages of AD. Saliva can be obtained easily, and ...
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Article
Open AccessMetformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice
Accumulation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau is a histopathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Growing evidence demonstrated that tau pa...
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Article
Open AccessMetformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice
The neuropathological hallmarks of Alzheimer’s disease (AD) are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). The amyloid cascade theory is the leading hypothesis of AD pathology. Aβ deposition pr...
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Article
Open AccessThe role of brain perivascular space burden in early-stage Parkinson’s disease
Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson’s disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS i...
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Article
Open AccessThe differential effects of isoflurane and sevoflurane on neonatal mice
Previous research has shown that exposure to volatile anesthetics can induce acute neuroinflammation and neuroapoptopsis in neonatal rodents and that these events can lead to cognitive dysfunction at later sta...
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Article
Open AccessCerebral sparganosis presenting with atypical postcontrast magnetic resonance imaging findings: a case report and literature review
Sparganosis, a rare and severe parasitic infection caused by the larvae of Spirometra species or simply sparganum, generally involves subcutaneous tissue or muscle. But occasionally, sparganum can also invade the...
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Molecular Connection Between Diabetes and Dementia
Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) are both serious global health problems with high prevalence. These two diseases have some common features, including risk factors, age-associated d...
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Article
Open AccessCerebral infarcts associated with adenomyosis: a rare risk factor for stroke in middle-aged women: a case series
Adenomyosis is a benign disease with elevated CA125 level.
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Article
Intranasal Insulin Ameliorates Cerebral Hypometabolism, Neuronal Loss, and Astrogliosis in Streptozotocin-Induced Alzheimer’s Rat Model
Intracerebroventricular injection of streptozotocin (ICV-STZ) in rodents leads to cognitive impairments and several pathological changes like Alzheimer’s disease (AD). However, there is hardly any research abo...
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Open AccessO-GlcNAcylation Reduces Ischemia-Reperfusion–Induced Brain Injury
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins with β-N-acetylglucosamine (GlcNAc) and regulates numerous biological processes. By using mouse models of cerebral ische...
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Article
Exosomes Secreted from HEK293-APP Swe/Ind Cells Impair the Hippocampal Neurogenesis
This study aimed to investigate the neurotoxicity of exosomes to cultured neuroblastoma and neurons in vitro and to mature and newborn neurons in the hippocampus in vivo. Recent in vitro and in vivo studies ha...
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Open AccessLong-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer’s rat model
Recent evidence reveals that aberrant brain insulin signaling plays an important role in the pathology of Alzheimer’s disease (AD). Intranasal insulin administration has been reported to improve memory and att...
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Article
Open AccessIntranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice
Elderly individuals are at increased risk of cognitive decline after anesthesia. General anesthesia is believed to be a risk factor for Alzheimer’s disease (AD). At present, there is no treatment that can prev...
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Article
Deregulation of brain insulin signaling in Alzheimer’s disease
Contrary to the previous belief that insulin does not act in the brain, studies in the last three decades have demonstrated important roles of insulin and insulin signal transduction in various functions of th...
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Article
Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice
Alzheimer's disease (AD) involves several possible molecular mechanisms, including impaired brain insulin signaling and glucose metabolism. To investigate the role of metabolic insults in AD, we injected strep...
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Pretreatment of PC12 Cells with 17β-estradiol Prevents Aβ-Induced Down-Regulation of CREB Phosphorylation and Prolongs Inhibition of GSK-3β
It is believed that estrogen protects neurons against various toxicities like that from amyloid β (Aβ) in Alzheimer’s disease (AD). In the present study, we investigated the effects of Aβ1–42 on the activities of...
