66 Result(s)

Article

Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer

FOXM1 is a potent oncogenic transcription factor essential for cancer initiation, progression, and drug resistance. FOXM1 regulatory network is a major predictor of adverse outcomes in various human cancers. I...

Zaixin Zhang, Si-tu Xue, Yan Gao, Yingwei Li, Ziying Zhou… in Cell Death Discovery (2022)

Article

Ca²⁺ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

Transmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining homeostasis of calcium (Ca²⁺) stores in the endoplasmic reticulum (ER). TMCO1-defect syndrome shares multiple features with hu...

Ke-Yan Yang, Song Zhao, Hai** Feng, Jiaqi Shen, Yuwei Chen… in Cell Death & Disease (2022)

Article

NOP53 undergoes liquid-liquid phase separation and promotes tumor radio-resistance

Aberrant DNA damage response (DDR) axis remains the major molecular mechanism for tumor radio-resistance. We recently characterized liquid-liquid phase separation (LLPS) as an essential mechanism of DDR, and i...

Jie Shi, Si-Ying Chen, **ao-Ting Shen, **n-Ke Yin, Wan-Wen Zhao… in Cell Death Discovery (2022)

Article

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines and antibody therapeutics. This calls for the variant-proof ...

Wei Pang, Ying Lu, Yan-Bo Zhao, Fan Shen, Chang-Fa Fan, Qian Wang… in Cell Research (2022)

Article

Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury

Alterations in phospholipids have long been associated with spinal cord injury (SCI). However, their specific roles and signaling cascades in mediating cell death and tissue repair remain unclear. Here we inve...

Nai-Kui Liu, Ling-**ao Deng, Miao Wang, Qing-Bo Lu, Chunyan Wang… in Cell Death & Disease (2022)

Article

Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma

Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, tr...

Wen-** Chen, Ke-qin Dong, **u-wu Pan, Si-shun Gan, Da Xu… in Cell Death & Disease (2023)

Article

Multiple variation patterns of terpene synthases in 26 maize genomes

Terpenoids are important compounds associated with the pest and herbivore resistance mechanisms of plants; consequently, it is essential to identify and explore terpene synthase (TPS) genes in maize. In the prese...

Yang Sun, Wenqing **ao, Qing-nan Wang, **g Wang, **ang-dong Kong… in BMC Genomics (2023)

Article

Whole exome sequencing with a focus on cardiac disease-associated genes in families of sudden unexplained deaths in Yunnan, southwest of China

To explore the causes of sudden unexpected death (SUD) and to search for high-risk people, whole exome sequencing (WES) was performed in families with SUDs. 

Si-Jie Wei, **-Liang Du, Yue-Bing Wang, Peng-Fei Qu, Lin Ma… in BMC Genomics (2023)

Article

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products

Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleoti...

Wei Li, Wang-Sheng Jiang, Ya-Ru Su, Ke-Wu Tu, Lin Zou… in Cell Death & Disease (2023)

Article

Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose

Yuemiao Zhang, Meng-Ting Luo, Qingqin Wu, Yun-**a Wang, Xupu Ma… in Cell Discovery (2023)

Article

P4-ATPase subunit Cdc50 plays a role in yeast budding and cell wall integrity in Candida glabrata

As highly-conserved types of lipid flippases among fungi, P4-ATPases play a significant role in various cellular processes. Cdc50 acts as the regulatory subunit of flippases, forming heterodimers with Drs2 to ...

Ke-Zhi Chen, Lu-Ling Wang, **-Yan Liu, Jun-Tao Zhao, Si-Jia Huang… in BMC Microbiology (2023)

Article

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this ca...

Tian-yue Liu, Chen-chen Hu, Chen-ying Han, Si-yi Mao, Wen-xin Zhang… in Biology Direct (2023)

Article

Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy

CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living with HIV-1 (PLWH). HIV-1 infection induces marked metabolic...

You-Yuan Wang, Cheng Zhen, Wei Hu, Hui-Huang Huang, Yan-Jun Li… in Communications Biology (2023)

Article

Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells

Extravillous trophoblast cell (EVT) differentiation and its communication with maternal decidua especially the leading immune cell type natural killer (NK) cell are critical events for placentation. However, a...

Bai-Mei Zhuang, Dan-Dan Cao, Tian-** Li, **ao-Feng Liu, Min-Min Lyu… in BMC Genomics (2023)

Article

SRSF2 is required for mRNA splicing during spermatogenesis

RNA splicing plays significant roles in fundamental biological activities. However, our knowledge about the roles of alternative splicing and underlying mechanisms during spermatogenesis is limited.

Wen-Long Lei, Zongchang Du, Tie-Gang Meng, Ruibao Su, Yuan-Yuan Li… in BMC Biology (2023)

Article

Correction: Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines

Yue-Ting Tang, Yi-Yao Huang, **g-Huan Li, Si-Hua Qin, Yong Xu, Tai-Xue An… in BMC Genomics (2023)