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Article
Open AccessIdentification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...
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Article
Investigation of wake-induced vibration interference between two staggered wave-cone cylinders at subcritical Reynolds number
The wake induced vibration (WIV) of a one- and two-degree-of-freedom (1DOF, 2DOF) downstream wave-cone cylinder (WCC) behind a stationary equal-size upstream wave-cone cylinder in the staggered arrangement is ...
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Article
Open AccessQSAR analysis of VEGFR-2 inhibitors based on machine learning, Topomer CoMFA and molecule docking
VEGFR-2 kinase inhibitors are clinically approved drugs that can effectively target cancer angiogenesis. However, such inhibitors have adverse effects such as skin toxicity, gastrointestinal reactions and hepa...
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Article
Well-Posedness in Gevrey Function Space for the 3D Axially Symmetric MHD Boundary Layer Equations Without Structural Assumption
In this paper, we establish the well-posedness theory for the three-dimensional axially symmetric magnetohydrodynamic (MHD) boundary layer system in Gevrey function space without any structural assumption. By ...
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Article
Open AccessLetter to the editor concerning “Association of hardware removal with secondary osteonecrosis following femoral neck fractures: a systematic review and meta-analysis”
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Chapter and Conference Paper
A Novel Spectral Sparse Classification Scheme with Applications to Intelligent Diagnostics of Wind Turbine Planetary Gearboxes
Intelligent diagnostics and prognostics can greatly promote the availability, durability, and reliability of wind turbines (WT), and meanwhile, save huge economic costs for the operation and maintenance of win...
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Article
Open AccessClinical study of a spray containing birch juice for repairing sensitive skin
Sensitive skin is described as an unpleasant sensory response to a stimulus that should not cause a sensation. Sensitive skin affects an increasing proportion of the population. Sixty-seven participants who te...
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Article
S1P-S1PR3-RAS promotes the progression of S1PR3hi TAL1+ T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist
TAL1+ T-cell acute lymphoblastic leukemia (T-ALL) is a distinct subtype of leukemia with poor outcomes. Through the cooperation of co-activators, including RUNX1, GATA3, and MYB, the TAL1 oncoprotein extends the ...
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Article
Open AccessLncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN
Oncogene MYCN is closely related with malignant progression and poor prognosis of neuroblastoma (NB). Recently, long non-coding RNAs (lncRNAs) have been recognized as crucial regulators in various cancers. Howeve...
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Article
Open AccessTreatment of Stretch Marks Using a New Formulation Combining Nanofractional Radiofrequency Plus Magnetic Nanofractional Radiofrequency
Stretch marks are common atrophic dermal scars with significant physical and psychological effects. Therefore, there is a need for effective cosmetics and procedures for stretch mark treatment. This study aime...
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Article
Predicting Drug Synergy and Discovering New Drug Combinations Based on a Graph Autoencoder and Convolutional Neural Network
Drug synergy is a crucial component in drug reuse since it solves the problem of sluggish drug development and the absence of corresponding drugs for several diseases. Predicting drug synergistic relationships...
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Article
Open AccessDiagnostic value of SHOX2, RASSF1A gene methylation combined with CEA level detection in malignant pleural effusion
To investigate the diagnostic value of combined detection of SHOX2 and RASSF1A gene methylation with carcinoembryonic antigen (CEA) level in diagnosing malignant pleural effusion.
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Article
A compact review of progress and prospects of deep learning in drug discovery
Drug discovery processes, such as new drug development, drug synergy, and drug repurposing, consume significant yearly resources. Computer-aided drug discovery can effectively improve the efficiency of drug di...
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Article
Open AccessPINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products
Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleoti...
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Chapter and Conference Paper
Vector Control Strategy of Permanent Magnet Synchronous Motor Based on Fuzzy PID Control
In recent years, the market demand for new energy vehicles is increasing, so more and more scholars are devoted to the research of this topic. Permanent magnet synchronous motors are widely used in the drive o...
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Article
Open AccessInhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
In neuroblastoma, hyperactivation of the PI3K signaling pathway has been correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the treatment of neuroblastoma. However, the oncoge...
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Article
Detection by environmental surveillance and genomic characterization of H5N8 highly pathogenic avian influenza virus from a poultry meat market in Bei**g, China, 2021–22
Since 2010 the year when it was first reported in domestic ducks in China, highly pathogenic avian influenza (HPAI) H5N8 has caused several outbreaks in different countries. The first outbreak wave was documen...
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Article
Mechanically robust and conductive poly(acrylamide) nanocomposite hydrogel by the synergistic effect of vinyl hybrid silica nanoparticle and polypyrrole for human motion sensing
Hydrogel-based sensors are playing important roles in artificial intelligence, benefiting from its flexibility and biocompatibility, whereas conventional hydrogels are fragile and electronically insulated in n...
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Article
Open AccessMatrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
Neuroblastoma (NB) is one of the most common malignant solid tumors in children. Despite significant advances in the treatment strategy, the long-term survival rate of NB patients is only 50%. Develo** new a...
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Article
Application of next generation sequencing in the screening of monogenic diseases in China, 2021: a consensus among Chinese newborn screening experts
