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Article
Open AccessA comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank
Alzheimer’s disease (AD) risk is increased in carriers of the apolipoprotein E (APOE) ε4 allele and decreased in ε2 allele carriers compared with the ε3ε3 genotype. The aim of this study was to determine whether:...
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Article
Open AccessHigh intake of ultra-processed food is associated with dementia in adults: a systematic review and meta-analysis of observational studies
Poor cardiometabolic health is associated with dementia. Considering previous meta-analyses have confirmed associations between ultra-processed foods (UPFs) and cardiometabolic disease, we were interested in t...
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Article
Open AccessMacrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study
Macrostructural brain alterations in the form of brain atrophy or cortical thinning typically occur during the prodromal Alzheimer’s disease stage. Mixed findings largely dependent on the age of the examined c...
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Article
Open AccessAuthor Correction: Map** brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations
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Article
Open AccessMap** brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations
Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have bee...
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Chapter and Conference Paper
Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging
We extend the sparse, spatially piecewise-contiguous linear classification framework for mesh-based data to ordinal logistic regression. The algorithm is intended for use with subcortical shape and cortical th...
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Article
Open AccessMultimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease
Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what d...
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Article
Open AccessExploring variability in basal ganglia connectivity with functional MRI in healthy aging
Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving...
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Article
Open AccessAllostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study
The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in ...
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Chapter and Conference Paper
Iterative Dual LDA: A Novel Classification Algorithm for Resting State fMRI
Resting-state functional MRI (rfMRI) provides valuable information about functional changes in the brain and is a strong candidate for biomarkers in neurodegenerative diseases. However, commonly used analysis ...
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Article
Using Structural and Diffusion Magnetic Resonance Imaging To Differentiate the Dementias
Dementia is one of the major causes of personal, societal and financial dependence in older people and in today’s ageing society there is a pressing need for early and accurate markers of cognitive decline. Th...
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Article
Open AccessStudy protocol: the Whitehall II imaging sub-study
The Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces ...
